Ppard<tm1.1Rev> Targeted Allele Detail MGI Mouse (MGI:2386684)

Ppard^tm1.1Rev
Targeted Allele Detail

Summary

Symbol:	Ppard^tm1.1Rev
Name:	peroxisome proliferator activator receptor delta; targeted mutation 1.1, Ronald M Evans
MGI ID:	MGI:2386684
Synonyms:	Ppardelta^-
Gene:	Ppard Location: Chr17:28451715-28520446 bp, + strand Genetic Position: Chr17, 14.64 cM
Alliance:	Ppard^tm1.1Rev page

Pathologies of Ppard^tm1.1Rev/Ppard^tm1.1Rev mouse placentas

Show the 2 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:73557
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Intragenic deletion
		Mutation details: Exon 4, which encodes the amino terminal portion of the DNA binding domain was excised along with a downstream neo cassette via the expression of cre recombinase in vitro. (J:73557)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Ppard Mutation:	68 strains or lines available

References

Original:	J:73557 Barak Y, et al., Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):303-8
All:	12 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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