Mafg<tm1Jeng> Targeted Allele Detail MGI Mouse (MGI:2386717)

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Mafg^tm1Jeng
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Mafg^tm1Jeng
Name:	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian); targeted mutation 1, James Douglas Engel
MGI ID:	MGI:2386717
Synonyms:	mafG-
Gene:	Mafg Location: Chr11:120515943-120524426 bp, - strand Genetic Position: Chr11, 84.35 cM
Alliance:	Mafg^tm1Jeng page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:78982
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout, Reporter)
Mutations:		Insertion, Intragenic deletion
		Mutation details: The entire coding region was replaced by a cassette containing lacZ and floxed tk-neo genes. The lacZ gene was situated immediately downstream of the translational start codon. RNAse protection assays were utilized to confirm the absence of transcript in homozygous mutant mice. Expression of beta-galactosidase was driven by the endogenous promoter. (J:78982)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	74 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Mafg Mutation:	38 strains or lines available

References

Original:	J:78982 Shavit JA, et al., Impaired megakaryopoiesis and behavioral defects in mafG-null mutant mice. Genes Dev. 1998 Jul 15;12(14):2164-74
All:	14 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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