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Nherf1tm1Ssl
Targeted Allele Detail
Summary
Symbol: Nherf1tm1Ssl
Name: NHERF family PDZ scaffold protein 1; targeted mutation 1, Shirish Shenolikar
MGI ID: MGI:2386785
Synonyms: Nherf1-, NHERF-1(-), NHERF1-
Gene: Nherf1  Location: Chr11:115054167-115072007 bp, + strand  Genetic Position: Chr11, 80.65 cM, cytoband E2
Alliance: Nherf1tm1Ssl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78606
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exon 1 was replaced by a neomycin selection cassette inserted by homologous recombination. Protein was undetected in homozygous mutant mice by Western blot analysis of kidney extracts and immunostaining of proximal renal tubules. (J:78606)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nherf1 Mutation:  18 strains or lines available
References
Original:  J:78606 Shenolikar S, et al., Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting. Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11470-5
All:  26 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory