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Ogg1tm1Tld
Targeted Allele Detail
Summary
Symbol: Ogg1tm1Tld
Name: 8-oxoguanine DNA-glycosylase 1; targeted mutation 1, Tomas Lindahl
MGI ID: MGI:2386943
Synonyms: ogg1-
Gene: Ogg1  Location: Chr6:113303959-113311149 bp, + strand  Genetic Position: Chr6, 52.75 cM, cytoband E-F1
Alliance: Ogg1tm1Tld page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:58517
Parent Cell Line:  GK129 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Sequences encoding the highly conserved helix-hairpin-helix motif required for enzyme activity were replaced by a neomycin selection cassette. (J:58517)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ogg1 Mutation:  23 strains or lines available
References
Original:  J:58517 Klungland A, et al., Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage. Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13300-5
All:  41 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory