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Gclctm1Mwl
Targeted Allele Detail
Summary
Symbol: Gclctm1Mwl
Name: glutamate-cysteine ligase, catalytic subunit; targeted mutation 1, Michael W Lieberman
MGI ID: MGI:2387010
Synonyms: gammaGCS-HStm1
Gene: Gclc  Location: Chr9:77661817-77701767 bp, + strand  Genetic Position: Chr9, 43.36 cM, cytoband D-E
Alliance: Gclctm1Mwl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62177
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A 1.3 kb region of the gene containing the TATA box and exon 1 was replaced with a PGK-Hprt cassette via homologous recombination. (J:62177)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gclc Mutation:  20 strains or lines available
References
Original:  J:62177 Shi ZZ, et al., Glutathione synthesis is essential for mouse development but not for cell growth in culture. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5101-6
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory