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Lnpep Gene Detail
Summary
  • Symbol
    Lnpep
  • Name
    leucyl/cystinyl aminopeptidase
  • Synonyms
    2010309L07Rik, 4732490P18Rik, gp160, IRAP, vp165
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387123
    NCBI Gene: 240028
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:17747985-17846303 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 9.77 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1989 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2387123
 protein coding gene Chr17:17741672-17846303 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023182
 protein coding gene Chr17:15518469-15611897 (-)
A/J MGP_AJ_G0023147
 protein coding gene Chr17:15182863-15273029 (-)
AKR/J MGP_AKRJ_G0023117
 protein coding gene Chr17:15247942-15343136 (-)
BALB/cJ MGP_BALBcJ_G0023147
 protein coding gene Chr17:15114187-15203164 (-)
C3H/HeJ MGP_C3HHeJ_G0022907
 protein coding gene Chr17:15461267-15551592 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023590
 protein coding gene Chr17:16304034-16407806 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021103
 protein coding gene Chr17:13034824-13118906 (-)
CAST/EiJ MGP_CASTEiJ_G0022426
 protein coding gene Chr17:15265230-15358322 (-)
CBA/J MGP_CBAJ_G0022884
 protein coding gene Chr17:16864219-16952618 (-)
DBA/2J MGP_DBA2J_G0023017
 protein coding gene Chr17:14885734-14975276 (-)
FVB/NJ MGP_FVBNJ_G0022985
 protein coding gene Chr17:14714441-14804630 (-)
LP/J MGP_LPJ_G0023091
 protein coding gene Chr17:15504389-15600544 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023006
 protein coding gene Chr17:16405789-16534082 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023627
 protein coding gene Chr17:15426973-15522682 (-)
PWK/PhJ MGP_PWKPhJ_G0022175
 protein coding gene Chr17:14521817-14615384 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022003
 protein coding gene Chr17:14465800-14554977 (-)
WSB/EiJ MGP_WSBEiJ_G0022485
 protein coding gene Chr17:15713633-15807203 (-)



Homology
more
  • Human Ortholog
    LNPEP, leucyl and cystinyl aminopeptidase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LNPEP, leucyl and cystinyl aminopeptidase
  • Synonyms
    CAP, IRAP, P-LAP, PLAP
  • Links
    NCBI Gene ID: 4012
    neXtProt AC: NX_Q9UIQ6
    UniProt: Q9UIQ6

  • Chr Location
    5q15; chr5:96935394-97037513 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 4 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a somewhat reduced tissue uptake of glucose either basally or after insulin stimulation. Mice homozygous for a different knock-out allele exhibit impaired coordination at 3 months and impaired spatial working memory in a Y maze at 6 months of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    3
  • cDNA Data
    15
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 240028 NCBI Gene Model | MGI Sequence Detail 98319 C57BL/6J ±  kb
    transcript NM_172827 RefSeq | MGI Sequence Detail 5181 C57BL/6  
    polypeptide Q8C129 UniProt | EBI | MGI Sequence Detail 1025 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000009874 leucyl-cystinyl aminopeptidase
      (term hierarchy)
    • EC
      3.4.11.-, 3.4.11.3
    • InterPro Domains
      IPR045357 Aminopeptidase N-like , N-terminal domain
      IPR042097 Aminopeptidase N-like , N-terminal domain superfamliy
      IPR034016 Aminopeptidase N-type
      IPR024571 ERAP1-like C-terminal domain
      IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
      IPR050344 Peptidase M1 family aminopeptidases
      IPR014782 Peptidase M1, membrane alanine aminopeptidase
      IPR027268 Peptidase M4/M1, CTD superfamily
    • GlyGen
      Q8C129 19 sites, 26 N-linked glycans (11 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1913735, MGI:2443260
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 1
      Gene Ontology 10
      Phenotypes 31
    • Earliest
      J:68323 Carninci P, et al., Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Genome Res. 2000 Oct;10(10):1617-30
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory