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Dab2tm1.1Cpr
Targeted Allele Detail
Summary
Symbol: Dab2tm1.1Cpr
Name: disabled 2, mitogen-responsive phosphoprotein; targeted mutation 1.1, Jonathan A Cooper
MGI ID: MGI:2387168
Synonyms: Dab2-
Gene: Dab2  Location: Chr15:6329269-6470193 bp, + strand  Genetic Position: Chr15, 2.15 cM, cytoband A2
Alliance: Dab2tm1.1Cpr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75911
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A floxed region containing exon 2, which encodes the phosphotyrosine binding (PTB) domain common to all known isoforms, was excised by in vitro cre mediated recombination. A single loxP site was left downstream of exon 1. (J:75911)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 19 assay results
In Structures Affected by this Mutation: 11 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dab2 Mutation:  53 strains or lines available
References
Original:  J:75911 Morris SM, et al., Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport. EMBO J. 2002 Apr 2;21(7):1555-64
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory