Fos<tm1Mxu> Targeted Allele Detail MGI Mouse (MGI:2387304)

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Fos^tm1Mxu
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Fos^tm1Mxu
Name:	FBJ osteosarcoma oncogene; targeted mutation 1, Ming Xu
MGI ID:	MGI:2387304
Synonyms:	f/fc-fos
Gene:	Fos Location: Chr12:85520664-85524047 bp, + strand Genetic Position: Chr12, 39.7 cM
Alliance:	Fos^tm1Mxu page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:75813
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: A region containing sequence encoding the DNA-binding and leucine zipper domains and a downstream neo transgene was flanked by single loxP sites. In situ hybridization and immunostaining indicated that the loxP sites did not interfere with transcription or translation. (J:75813)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Fos Mutation:	43 strains or lines available

References

Original:	J:75813 Zhang J, et al., c-fos regulates neuronal excitability and survival. Nat Genet. 2002 Apr;30(4):416-20
All:	14 reference(s)

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