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Tcf12tm1Zhu
Targeted Allele Detail
Summary
Symbol: Tcf12tm1Zhu
Name: transcription factor 12; targeted mutation 1, Yuan Zhuang
MGI ID: MGI:2387400
Synonyms: HEB-, HEBko
Gene: Tcf12  Location: Chr9:71751534-72019611 bp, - strand  Genetic Position: Chr9, 39.85 cM
Alliance: Tcf12tm1Zhu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:43324
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The insertion of a neomycin selection cassette deleted sequence encoding the 3' portion of the basic helix-loop-helix (bHLH) domain. The disruption of the bHLH precludes dimerization, thereby preventing the potential for DNA binding activity. (J:43324)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcf12 Mutation:  75 strains or lines available
References
Original:  J:43324 Zhuang Y, et al., B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB. Mol Cell Biol. 1996 Jun;16(6):2898-905
All:  15 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory