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Tg(SERPINA1-cre/ERT)1Ipc
Transgene Detail
Summary
Symbol: Tg(SERPINA1-cre/ERT)1Ipc
Name: transgene insertion 1, I Pierre Chambon
MGI ID: MGI:2387444
Synonyms: alphaAT-cre-ERT, Tg(SERPINA1-cre/ESR1)1Ipc
Transgene: Tg(SERPINA1-cre/ERT)1Ipc  Location: unknown  
Alliance: Tg(SERPINA1-cre/ERT)1Ipc page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tg(SERPINA1-cre/ERT)1Ipc expression driven by 1 gene
 
Mutation details: This transgenic construct encodes a tamoxifen-inducible cre recombinase protein. A human SERPINA1 promoter was adjoined to a sequence encoding a fusion protein consisting of cre recombinase and a mutated human estrogen receptor ligand-binding domain, to drive expression in hepatocytes. The ligand-binding domain possesses a substitution mutation at position 521, converting the region from an estradiol binding domain to a tamoxifen binding domain. In situ hybridization and immunohistochemical analysis showed expression in 40% to 50% of hepatocytes. (J:69327)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: SERPINA1 (human)
Summary of all recombinase alleles driven by SERPINA1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:69327 Imai T, et al., Inducible site-specific somatic mutagenesis in mouse hepatocytes. Genesis. 2000 Feb;26(2):147-8
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/12/2024
MGI 6.24 		The Jackson Laboratory