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Rps6tm1Gtho
Targeted Allele Detail
Summary
Symbol: Rps6tm1Gtho
Name: ribosomal protein S6; targeted mutation 1, George Thomas
MGI ID: MGI:2387471
Synonyms: fS6, Rps6lox, S6lox
Gene: Rps6  Location: Chr4:86772897-86775649 bp, - strand  Genetic Position: Chr4, 40.69 cM, cytoband C3
Alliance: Rps6tm1Gtho page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62795
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: Exons 3 through 5 were flanked by a single loxP site inserted into intron 2 and a downstream neo cassette with a 3' loxP site. Northern blot analysis verified that the floxed allele was expressed in liver tissue. (J:62795)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rps6 Mutation:  12 strains or lines available
References
Original:  J:62795 Volarevic S, et al., Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6. Science. 2000 Jun 16;288(5473):2045-7
All:  8 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory