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Plekhn1 Gene Detail
Summary
  • Symbol
    Plekhn1
  • Name
    pleckstrin homology domain containing, family N member 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387630
    NCBI Gene: 231002
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:156305913-156312999 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 88.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    488 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2387630
 protein coding gene Chr4:156305913-156314174 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029251
 protein coding gene Chr4:160594602-160601687 (-)
A/J MGP_AJ_G0029216
 protein coding gene Chr4:153827557-153834631 (-)
AKR/J MGP_AKRJ_G0029164
 protein coding gene Chr4:158019827-158026912 (-)
BALB/cJ MGP_BALBcJ_G0029232
 protein coding gene Chr4:154304350-154311424 (-)
C3H/HeJ MGP_C3HHeJ_G0028953
 protein coding gene Chr4:158593027-158600101 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029681
 protein coding gene Chr4:166297094-166304180 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026924
 protein coding gene Chr4:146104068-146111503 (-)
CAST/EiJ MGP_CASTEiJ_G0028365
 protein coding gene Chr4:156015709-156024197 (-)
CBA/J MGP_CBAJ_G0028915
 protein coding gene Chr4:171347454-171354534 (-)
DBA/2J MGP_DBA2J_G0029064
 protein coding gene Chr4:153846359-153853433 (-)
FVB/NJ MGP_FVBNJ_G0029027
 protein coding gene Chr4:153098301-153105386 (-)
LP/J MGP_LPJ_G0029154
 protein coding gene Chr4:160549238-160556312 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029054
 protein coding gene Chr4:174117463-174124548 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029713
 protein coding gene Chr4:158651666-158658760 (-)
PWK/PhJ MGP_PWKPhJ_G0028085
 protein coding gene Chr4:149988104-149995301 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027919
 protein coding gene Chr4:152901695-152908816 (-)
WSB/EiJ MGP_WSBEiJ_G0028445
 protein coding gene Chr4:158834018-158841069 (-)



Homology
more
  • Human Ortholog
    PLEKHN1, pleckstrin homology domain containing N1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLEKHN1, pleckstrin homology domain containing N1
  • Synonyms
    CLPABP
  • Links
    NCBI Gene ID: 84069
    neXtProt AC: NX_Q494U1
    UniProt: Q494U1

  • Chr Location
    1p36.33; chr1:966482-975865 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Older male mice homozygous for a knock-out allele develop obesity associated with increased epididymal fat pad and liver weight, hyperphagia and increased circulating leptin levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 231002 NCBI Gene Model | MGI Sequence Detail 7087 C57BL/6J ±  kb
    transcript NM_001008233 RefSeq | MGI Sequence Detail 2210 C57BL/6  
    polypeptide Q8C886 UniProt | EBI | MGI Sequence Detail 610 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000029680 pleckstrin homology domain-containing family N member 1
      (term hierarchy)
    • InterPro Domains
      IPR011993 PH-like domain superfamily
      IPR001849 Pleckstrin homology domain
      IPR042835 Pleckstrin homology domain-containing family N member 1
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 24

      Microarray probesets 2
    References
    more
    • Summaries
      All 23
      Gene Ontology 6
      Phenotypes 2
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:251603 Nishino T, et al., Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse. Biochim Biophys Acta. 2016 Nov;1861(11):1816-1827
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory