Cdk5r2tm1Lht
Targeted Allele Detail
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| Symbol: |
Cdk5r2tm1Lht |
| Name: |
cyclin dependent kinase 5, regulatory subunit 2; targeted mutation 1, Li-Huei Tsai |
| MGI ID: |
MGI:2387662 |
| Synonyms: |
p39- |
| Gene: |
Cdk5r2 Location: Chr1:74894188-74896891 bp, + strand Genetic Position: Chr1, 38.54 cM, cytoband C3
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| Alliance: |
Cdk5r2tm1Lht page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:71181
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| Parent Cell Line: |
J1 (ES Cell)
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| Strain of Origin: |
129S4/SvJae
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin resistance cassette in the reverse orientation replaced 1 kb of the coding region resulting in deletion of amino acids 1-346 and 100 bp of upstream noncoding sequences. Absence of gene expression in homozygous animals was demonstrated by Western blot analysis of whole brain lysates. Histone 1 kinase activity is also absent in brain lysates of homozygous mutant animals.
(J:71181)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Cdk5r2 Mutation: |
9 strains or lines available
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| Original: |
J:71181 Ko J, et al., p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. J Neurosci. 2001 Sep 1;21(17):6758-71 |
| All: |
10 reference(s) |
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Analysis Tools
