Pou4f1<tm1Nat> Targeted Allele Detail MGI Mouse (MGI:2387665)

Pou4f1^tm1Nat
Targeted Allele Detail

Summary

Symbol:	Pou4f1^tm1Nat
Name:	POU domain, class 4, transcription factor 1; targeted mutation 1, Jeremy Nathans
MGI ID:	MGI:2387665
Synonyms:	Brn-3a-
Gene:	Pou4f1 Location: Chr14:104699112-104705435 bp, - strand Genetic Position: Chr14, 54.21 cM, cytoband E1-E3
Alliance:	Pou4f1^tm1Nat page

Behavioral differences between +/+ wild-type and Pou4f1^tm1Nat/Pou4f1^tm1Nat mice at birth

Show the 6 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:35877
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: The entire coding region of the endogenous locus was replaced with a neomycin selection cassette inserted by homologous recombination. Immunohistochemical analysis of retinal tissue verified that protein was not produced by the targeted locus. (J:35877)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	179 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Pou4f1 Mutation:	13 strains or lines available

References

Original:	J:35877 Xiang M, et al., Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling. Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11950-5
All:	35 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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