Slatm1Weis
Targeted Allele Detail
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| Symbol: |
Slatm1Weis |
| Name: |
src-like adaptor; targeted mutation 1, Arthur Weiss |
| MGI ID: |
MGI:2387691 |
| Synonyms: |
SLAP- |
| Gene: |
Sla Location: Chr15:66652668-66703678 bp, - strand Genetic Position: Chr15, 29.3 cM
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| Alliance: |
Slatm1Weis page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:71804
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
129
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The gene was disrupted by replacement of part of the promoter region and sequences encoding the first 21 amino acids with a neomycin resistance cassette. Northern blot using a probe to the C-terminal region of the gene and RT-PCR analysis of homozygous animals confirmed inactivation of the gene. Sequence analysis of a weak RT-PCR product revealed an alternatively spliced truncated transcript.
(J:71804)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Original: |
J:71804 Sosinowski T, et al., The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection. Immunity. 2001 Sep;15(3):457-66 |
| All: |
14 reference(s) |
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Analysis Tools
