St3gal1tm1Jxm
Targeted Allele Detail
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| Symbol: |
St3gal1tm1Jxm |
| Name: |
ST3 beta-galactoside alpha-2,3-sialyltransferase 1; targeted mutation 1, Jamey Marth |
| MGI ID: |
MGI:2387752 |
| Synonyms: |
ST3Gal-Idelta |
| Gene: |
St3gal1 Location: Chr15:66974724-67048575 bp, - strand Genetic Position: Chr15, 29.3 cM
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| Alliance: |
St3gal1tm1Jxm page
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 2 was flanked by loxP sites and a loxP-tk-neo cassette was inserted into the upstream intron via homologous recombination. Transient expression of cre recominase in correctly targeted cells facilitated the removal of exon 2 and the loxP-tk-neo cassette resulting in deletion of the sialyl motif essential for catalysis.
(J:79167)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any St3gal1 Mutation: |
41 strains or lines available
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| Original: |
J:79167 Priatel JJ, et al., The ST3Gal-I sialyltransferase controls CD8+ T lymphocyte homeostasis by modulating O-glycan biosynthesis. Immunity. 2000 Mar;12(3):273-83 |
| All: |
9 reference(s) |
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Analysis Tools
