Etv4<tm1Arbr> Targeted Allele Detail MGI Mouse (MGI:2387770)

Etv4^tm1Arbr
Targeted Allele Detail

Summary

Symbol:	Etv4^tm1Arbr
Name:	ets variant 4; targeted mutation 1, Silvia Arber
MGI ID:	MGI:2387770
Synonyms:	Etv4^-, Etv4^lacZ, Pea3^nlslacZ, Pea3^NLZ
Gene:	Etv4 Location: Chr11:101660568-101676197 bp, - strand Genetic Position: Chr11, 65.48 cM
Alliance:	Etv4^tm1Arbr page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:78717
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout, Reporter)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A portion of exon 6 and all of exons 7 through 11 were replaced with a cassette containing IRES-NLS-lacZ followed by a polyadenylation signal and neo gene. (J:78717)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	32 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Etv4^tm1Arbr

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Etv4 Mutation:	41 strains or lines available

References

Original:	J:78717 Livet J, et al., ETS gene Pea3 controls the central position and terminal arborization of specific motor neuron pools. Neuron. 2002 Aug 29;35(5):877-92
All:	22 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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