About   Help   FAQ
Sod1tm1Dkd
Targeted Allele Detail
Summary
Symbol: Sod1tm1Dkd
Name: superoxide dismutase 1, soluble; targeted mutation 1, Dipak K Das
MGI ID: MGI:2387861
Synonyms: Cu/ZnSOD-KO, Sod 1-
Gene: Sod1  Location: Chr16:90017650-90023221 bp, + strand  Genetic Position: Chr16, 51.56 cM, cytoband B5-C3
Alliance: Sod1tm1Dkd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60470
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The gene was disrupted by replacement of exon 5 and flanking intronic sequences with a neomycin resistance cassette via homologous recombination. The mutation deletes C-terminal amino acids 120-154 which constitute the structure and function of the active site channel. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot analysis of heart tissue. (J:60470)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sod1 Mutation:  40 strains or lines available
References
Original:  J:60470 Yoshida T, et al., Targeted disruption of the mouse Sod I gene makes the hearts vulnerable to ischemic reperfusion injury. Circ Res. 2000 Feb 18;86(3):264-9
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory