Kcnc2tm1Rudy
Targeted Allele Detail
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| Symbol: |
Kcnc2tm1Rudy |
| Name: |
potassium voltage gated channel, Shaw-related subfamily, member 2; targeted mutation 1, Bernardo Rudy |
| MGI ID: |
MGI:2387957 |
| Synonyms: |
Kv3.2 - |
| Gene: |
Kcnc2 Location: Chr10:112107026-112302929 bp, + strand Genetic Position: Chr10, 60.3 cM
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| Alliance: |
Kcnc2tm1Rudy page
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A 3' portion of exon 1, encoding the tetramerization domain (T domain) involved in oligomerization of potassium voltage gated channel subunits, was replaced by a neomycin selection cassette inserted by homologous recombination. Neither transcript nor protein was detected by Northern and Western blot analyses of homozygous mutant mice.
(J:66730)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Kcnc2 Mutation: |
30 strains or lines available
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| Original: |
J:66730 Lau D, et al., Impaired fast-spiking, suppressed cortical inhibition, and increased susceptibility to seizures in mice lacking kv3.2 K+ channel proteins. J Neurosci. 2000 Dec 15;20(24):9071-85 |
| All: |
8 reference(s) |
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Analysis Tools
