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Grin3atm1Nnk
Targeted Allele Detail
Summary
Symbol: Grin3atm1Nnk
Name: glutamate receptor ionotropic, NMDA3A; targeted mutation 1, Nobuki Nakanishi
MGI ID: MGI:2387963
Synonyms: NR3A-
Gene: Grin3a  Location: Chr4:49661611-49845744 bp, - strand  Genetic Position: Chr4, 26.72 cM
Alliance: Grin3atm1Nnk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66481
Parent Cell Line:  C1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The region encoding the N-terminal 118 amino acids (including the translation initation codon) was replaced with a PGK-neo cassette via homologous recombination. Homozygous mutant animals lacked gene expression as demonstrated by Northern and Western blot analysis of brain samples. (J:66481)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grin3a Mutation:  50 strains or lines available
References
Original:  J:66481 Das S, et al., Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A. Nature. 1998 May 28;393(6683):377-81
All:  24 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory