Ddr1<tm1Wfv> Targeted Allele Detail MGI Mouse (MGI:2388024)

Ddr1^tm1Wfv
Targeted Allele Detail

Summary

Symbol:	Ddr1^tm1Wfv
Name:	discoidin domain receptor family, member 1; targeted mutation 1, Wolfgang F Vogel
MGI ID:	MGI:2388024
Synonyms:	DDR1^-
Gene:	Ddr1 Location: Chr17:35992459-36015513 bp, - strand Genetic Position: Chr17, 18.7 cM, cytoband C
Alliance:	Ddr1^tm1Wfv page

Skull comparison of Ddr1^tm1Wfv/Ddr1^tm1Wfv, Ddr2^tm1Kln/Ddr2^tm1Kln and Ddr2^tm1Kln/Ddr2⁺ mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:68368
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Exon 1-12 were deleted and replaced with a neomycin resistance gene via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of embryonic protein extracts. (J:68368)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	28 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Ddr1 Mutation:	35 strains or lines available

References

Original:	J:68368 Vogel WF, et al., Discoidin domain receptor 1 tyrosine kinase has an essential role in mammary gland development. Mol Cell Biol. 2001 Apr;21(8):2906-17
All:	29 reference(s)

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