Tgfbr1tm1Karl
Targeted Allele Detail
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| Symbol: |
Tgfbr1tm1Karl |
| Name: |
transforming growth factor, beta receptor I; targeted mutation 1, Stefan Karlsson |
| MGI ID: |
MGI:2388050 |
| Synonyms: |
Alk5-, TbetaRI- |
| Gene: |
Tgfbr1 Location: Chr4:47353258-47414926 bp, + strand Genetic Position: Chr4, 26.02 cM
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| Alliance: |
Tgfbr1tm1Karl page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:68770
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| Parent Cell Line: |
Other (see notes) (ES Cell)
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| Strain of Origin: |
129
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A single loxP site remained in place of exon 3 after an upstream floxed neo cassette and downstream loxP site were recombined by transient expression of cre recombinase in targeted ES cells. The mutation results in deletion of the transmembrane domain and the GS domain required for protein function. Northern blot analysis using a full-length cDNA probe did not detect transcripts in endothelial cells from homozygous mutant embryos.
(J:68770)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Tgfbr1 Mutation: |
36 strains or lines available
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ES cell line = R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+) or GS (129S6/SvEvTac).
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| Original: |
J:68770 Larsson J, et al., Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice. EMBO J. 2001 Apr 2;20(7):1663-73 |
| All: |
21 reference(s) |
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Analysis Tools
