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Stamtm1Sug
Targeted Allele Detail
Summary
Symbol: Stamtm1Sug
Name: signal transducing adaptor molecule (SH3 domain and ITAM motif) 1; targeted mutation 1, Kazuo Sugamura
MGI ID: MGI:2388123
Synonyms: STAM1-/-
Gene: Stam  Location: Chr2:14078912-14152351 bp, + strand  Genetic Position: Chr2, 10.36 cM, cytoband A2-B
Alliance: Stamtm1Sug page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:69504
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The gene was disrupted by replacement of exons 3 and 4 encoding amino acids 44-99 with a neomycin resistance cassette. RT-PCR analysis of splenocyte RNA from homozygous mutant animals detected a mutant transcript with a frameshift and nonsense codon in exon 5. Western blot analysis of neocortex lysates and immunoprecipitation immunoblot of activated T cells from homozygous mutant animals did not detect a protein product. (J:69504)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Stam Mutation:  43 strains or lines available
References
Original:  J:69504 Yamada M, et al., Loss of hippocampal CA3 pyramidal neurons in mice lacking STAM1. Mol Cell Biol. 2001 Jun;21(11):3807-19
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory