Tg(Prph1)1Jpj Transgene Detail MGI Mouse (MGI:2182110)

Tg(Prph1)1Jpj
Transgene Detail

Summary

Symbol:	Tg(Prph1)1Jpj
Name:	transgene insertion 1, Jean-Pierre Julien
MGI ID:	MGI:2182110
Synonyms:	Per
Transgene:	Tg(Prph1)1Jpj Location: unknown
Alliance:	Tg(Prph1)1Jpj page

Transgene
origin

Strain of Origin:

(C57BL/6 x C3H)F1

Transgene
description

Transgene Type:

Transgenic (Inserted expressed sequence)

Mutation:

Insertion

Tg(Prph1)1Jpj expresses 1 gene

Mutation details: The full mouse Prph1 sequence including the endogenous promoter, 3.4 kb of 5' and 2.5 kb of 3' untranslated sequences was used for the transgene. (J:58388)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Transgenic animals carry 20 copies of the transgene and begin to develop motor dysfunctions after 2 years of age. Protein expression is increased 7-fold in the ventral roots and 3-fold in the dorsal roots of transgenic animals as determined by Western blot analysis.

References

Original:	J:58388 Beaulieu JM, et al., Late onset death of motor neurons in mice overexpressing wild-type peripherin. J Cell Biol. 1999 Nov 1;147(3):531-44
All:	5 reference(s)

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