Dab1tm2Cpr
Targeted Allele Detail
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| Symbol: |
Dab1tm2Cpr |
| Name: |
disabled 1; targeted mutation 2, Jonathan A Cooper |
| MGI ID: |
MGI:2388292 |
| Synonyms: |
Dab1-, dab1-5Fki |
| Gene: |
Dab1 Location: Chr4:103476556-104602041 bp, + strand Genetic Position: Chr4, 47.79 cM
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| Alliance: |
Dab1tm2Cpr page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:79475
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| Parent Cell Line: |
AK7 (ES Cell)
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| Strain of Origin: |
129S4/SvJaeSor
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| Allele Type: |
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Targeted |
| Mutations: |
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Insertion, Intragenic deletion, Nucleotide substitutions
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Mutation details: To generate an allele lacking phosphorylation sites, the exon encoding amino acids 23 through 69 was replaced with a construct containing a splice acceptor and a modified partial cDNA encoding the p80 splice form. The cDNA was modified to encode phenylalanines in place of the 5 tyrosines residues (185, 198, 200, 220, 232) that are potential phosphorylation sites. Phosphorylation levels were undetectable by phosphopeptide analysis of protein produced by the targeted allele in vitro.
(J:79475)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Dab1 Mutation: |
79 strains or lines available
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| Original: |
J:79475 Howell BW, et al., Dab1 tyrosine phosphorylation sites relay positional signals during mouse brain development. Curr Biol. 2000 Jul 27-Aug 10;10(15):877-85 |
| All: |
10 reference(s) |
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Analysis Tools
