Sag<tm1Jnc> Targeted Allele Detail MGI Mouse (MGI:2388373)

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Sag^tm1Jnc
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Sag^tm1Jnc
Name:	S-antigen, retina and pineal gland (arrestin); targeted mutation 1, Jeannie Chen
MGI ID:	MGI:2388373
Synonyms:	arr1-, Arrb1^tm1Jnc, arrestin^-
Gene:	Sag Location: Chr1:87731402-87772880 bp, + strand Genetic Position: Chr1, 44.44 cM
Alliance:	Sag^tm1Jnc page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:43294
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEv

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Part of the 5' promoter and exons 1 and 2 were replaced with a neomycin resistance cassette via homologous recombination. Gene expression was undetectable in rod cells of homozygous mutant animals as shown by Western blot analysis. (J:43294)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 9 strains available Cell Lines: 0 lines available
Carrying any Sag Mutation:	44 strains or lines available

References

Original:	J:43294 Xu J, et al., Prolonged photoresponses in transgenic mouse rods lacking arrestin. Nature. 1997 Oct 2;389(6650):505-9
All:	44 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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