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Drd2tm1Schm
Targeted Allele Detail
Summary
Symbol: Drd2tm1Schm
Name: dopamine receptor D2; targeted mutation 1, Claudia Schmauss
MGI ID: MGI:2388386
Synonyms: D2 -, D2R-KO
Gene: Drd2  Location: Chr9:49251927-49319477 bp, + strand  Genetic Position: Chr9, 26.72 cM
Alliance: Drd2tm1Schm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79483
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A 3' portion of exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded the amino terminal extracellular domain, transmembrane spanning domains 1 and 2, and the first intracellular domain. Transcript was undetected by Northern blot analysis of RNA obtained from the dorsal striatum of homozygous mutant mice. (J:79483)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Drd2 Mutation:  70 strains or lines available
References
Original:  J:79483 Jung MY, et al., Potentiation of the D2 mutant motor phenotype in mice lacking dopamine D2 and D3 receptors. Neuroscience. 1999;91(3):911-24
All:  13 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory