Trp53tm1Mok
Targeted Allele Detail
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| Symbol: |
Trp53tm1Mok |
| Name: |
transformation related protein 53; targeted mutation 1, Motoya Katsuki |
| MGI ID: |
MGI:2388704 |
| Gene: |
Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
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| Alliance: |
Trp53tm1Mok page
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| Mouse Generated: |
Earliest citation of chimera generation:
J:79629
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| Parent Cell Line: |
CCE/EK.CCE (ES Cell)
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| Strain of Origin: |
129S/SvEv-Gpi1c
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The gene was disrupted by replacment of exons 2-10 with a neo-TK cassette via homologous recombination. Germline founder animals were established but did not transmit the mutant allele to offspring, indicating a 100% segregation distortion. Authors hypothesize the HSV-TK gene is responsible for the lack of allele transmission.
(J:79629)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Trp53 Mutation: |
240 strains or lines available
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| Original: |
J:79629 Gondo Y, et al., Gene replacement of the p53 gene with the lacZ gene in mouse embryonic stem cells and mice by using two steps of homologous recombination. Biochem Biophys Res Commun. 1994 Jul 29;202(2):830-7 |
| All: |
1 reference(s) |
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Analysis Tools
