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Abca13 Gene Detail
Summary
  • Symbol
    Abca13
  • Name
    ATP-binding cassette, sub-family A member 13
  • Synonyms
    A930002G16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2388707
    NCBI Gene: 268379
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:9141942-9634259 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 6.13 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    14749 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2388707
 protein coding gene Chr11:9141942-9634871 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018041
 protein coding gene Chr11:6440301-6945890 (+)
A/J MGP_AJ_G0018014
 protein coding gene Chr11:6163597-6662681 (+)
AKR/J MGP_AKRJ_G0017978
 protein coding gene Chr11:6385880-6909795 (+)
BALB/cJ MGP_BALBcJ_G0017982
 protein coding gene Chr11:6155399-6676588 (+)
C3H/HeJ MGP_C3HHeJ_G0017795
 protein coding gene Chr11:6304054-6827231 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018434
 protein coding gene Chr11:6596844-7152522 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016092
 protein coding gene Chr11:5885175-6356785 (+)
CAST/EiJ MGP_CASTEiJ_G0017357
 protein coding gene Chr11:6327799-6843568 (+)
CBA/J MGP_CBAJ_G0017770
 protein coding gene Chr11:7160524-7721087 (+)
DBA/2J MGP_DBA2J_G0017880
 protein coding gene Chr11:6121223-6611653 (+)
FVB/NJ MGP_FVBNJ_G0017872
 protein coding gene Chr11:6070740-6554450 (+)
LP/J MGP_LPJ_G0017951
 protein coding gene Chr11:6476931-6986094 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017898
 protein coding gene Chr11:6707813-7277849 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018474
 protein coding gene Chr11:6530928-7026635 (+)
PWK/PhJ MGP_PWKPhJ_G0017137
 protein coding gene Chr11:6098455-6618916 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016934
 protein coding gene Chr11:6352414-6817293 (+)
WSB/EiJ MGP_WSBEiJ_G0017411
 protein coding gene Chr11:6269703-6784829 (+)



Homology
more
  • Human Ortholog
    ABCA13, ATP binding cassette subfamily A member 13
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABCA13, ATP binding cassette subfamily A member 13
  • Links
    NCBI Gene ID: 154664
    neXtProt AC: NX_Q86UQ4
    UniProt: Q86UQ4

  • Chr Location
    7p12.3; chr7:48171458-48647497 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ABCA13 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced prepulse inhibition and vesicular cholesterol accumulation and synaptic vesicle endocytosis are impaired in primary cortical neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    825
  • Tissues
    111
  • cDNA Data
    13
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004668 Ensembl Gene Model | MGI Sequence Detail 492318 C57BL/6J ±  kb
    transcript ENSMUST00000042740 Ensembl | MGI Sequence Detail 16011 Not Applicable  
    polypeptide ENSMUSP00000040465 Ensembl | MGI Sequence Detail 5034 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 13
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144330
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory