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Canxtm1Den
Targeted Allele Detail
Summary
Symbol: Canxtm1Den
Name: calnexin; targeted mutation 1, Angela Denzel
MGI ID: MGI:2388893
Synonyms: cnx-
Gene: Canx  Location: Chr11:50184788-50216500 bp, - strand  Genetic Position: Chr11, 30.46 cM
Alliance: Canxtm1Den page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79604
Parent Cell Line:  GK129 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A fragment encompassing 137 bp of exon 4, intron 4, and all of exon 5 was replaced with a floxed selection cassette. Protein was undetected in homozygous mutant mice by Western blot analysis using amino- and carboxyl-terminal antibodies. (J:79604)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Canx Mutation:  55 strains or lines available
References
Original:  J:79604 Denzel A, et al., Early postnatal death and motor disorders in mice congenitally deficient in calnexin expression. Mol Cell Biol. 2002 Nov;22(21):7398-404
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory