Canxtm1Den
Targeted Allele Detail
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|
| Symbol: |
Canxtm1Den |
| Name: |
calnexin; targeted mutation 1, Angela Denzel |
| MGI ID: |
MGI:2388893 |
| Synonyms: |
cnx- |
| Gene: |
Canx Location: Chr11:50184788-50216500 bp, - strand Genetic Position: Chr11, 30.46 cM
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| Alliance: |
Canxtm1Den page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:79604
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| Parent Cell Line: |
GK129 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A fragment encompassing 137 bp of exon 4, intron 4, and all of exon 5 was replaced with a floxed selection cassette. Protein was undetected in homozygous mutant mice by Western blot analysis using amino- and carboxyl-terminal antibodies.
(J:79604)
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| Key: |
| hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
|
Genotype/
Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
|---|
Loading... | | | involves: 129P2/OlaHsd * C57BL/6 | |
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| Phenotypes: |
| Affected Systems |
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behavior/neurological
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√
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novel environmental response-related retropulsion
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√
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ataxia
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√
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positive geotaxis
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√
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growth/size/body
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√
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decreased body size
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√
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mortality/aging
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√
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postnatal lethality, incomplete penetrance
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√
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nervous system
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√
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abnormal nervous system morphology
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Canx Mutation: |
55 strains or lines available
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|
| Original: |
J:79604 Denzel A, et al., Early postnatal death and motor disorders in mice congenitally deficient in calnexin expression. Mol Cell Biol. 2002 Nov;22(21):7398-404 |
| All: |
2 reference(s) |
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Analysis Tools
