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Cacnb3tm1Acv
Targeted Allele Detail
Summary
Symbol: Cacnb3tm1Acv
Name: calcium channel, voltage-dependent, beta 3 subunit; targeted mutation 1, Adolfo Cavalie
MGI ID: MGI:2389248
Synonyms: Beta3-
Gene: Cacnb3  Location: Chr15:98528721-98542410 bp, + strand  Genetic Position: Chr15, 54.64 cM
Alliance: Cacnb3tm1Acv page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79744
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A portion of exon 3 and all of exon 4 were replaced with a neomycin selection cassette inserted by homologous recombination. Northern and Western blot analyses of homozygous mutant mice indicated an absence of transcript and protein. (J:79744)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 6 assay results
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cacnb3 Mutation:  26 strains or lines available
References
Original:  J:79744 Murakami M, et al., Pain perception in mice lacking the beta3 subunit of voltage-activated calcium channels. J Biol Chem. 2002 Oct 25;277(43):40342-51
All:  13 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory