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Gt(ROSA)26Sortm1(FLP1)Dym
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm1(FLP1)Dym
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Susan Dymecki
MGI ID: MGI:2429412
Synonyms: CAGGS-Flpe, flipper, FLP, FLP deleter, FLPe, FLPeR, R26Fki, R26FLPe, ROSA26Fki, ROSA26::FLPe knock in
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm1(FLP1)Dym page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66893
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Gt(ROSA)26Sortm1(FLP1)Dym expression driven by 1 gene
 
Mutation details: An enhanced flp cassette containing a splice acceptor site was ligated to a downstream PGK-neo cassette and inserted at the endogenous locus. Efficient frt-specific recombination in transgenic mice carrying a reporter gene was reported to reflect constituitive expression of the Gt(ROSA)26Sor from preimplantation onward. (J:66893, J:92442)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gt(ROSA)26Sor (mouse)
Summary of all recombinase alleles driven by Gt(ROSA)26Sor.
 

Tumor Data
List all tumor models in MMHCdb carrying Gt(ROSA)26Sortm1(FLP1)Dym
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  993 strains or lines available
References
Original:  J:66893 Farley FW, et al., Widespread recombinase expression using FLPeR (Flipper) mice. Genesis. 2000 Nov-Dec;28(3-4):106-10
All:  828 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory