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Dab2tm1Xxx
Targeted Allele Detail
Summary
Symbol: Dab2tm1Xxx
Name: disabled 2, mitogen-responsive phosphoprotein; targeted mutation 1, Xiang-Xi Xu
MGI ID: MGI:2429678
Synonyms: dab2-
Gene: Dab2  Location: Chr15:6329269-6470193 bp, + strand  Genetic Position: Chr15, 2.15 cM, cytoband A2
Alliance: Dab2tm1Xxx page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79862
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The gene was disrupted by replacement of exons 2-6 with a promoter-less beta-geo cassette resulting in a fusion of the first 12 amino acids with beta-galactosidase. Reporter gene expression was not specified. (J:79862)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 26 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dab2 Mutation:  53 strains or lines available
References
Original:  J:79862 Yang DH, et al., Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis. Dev Biol. 2002 Nov 1;251(1):27-44
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory