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Hmox1tm1Mlee
Targeted Allele Detail
Summary
Symbol: Hmox1tm1Mlee
Name: heme oxygenase 1; targeted mutation 1, Mu-En Lee
MGI ID: MGI:2429784
Synonyms: hmox-1-, HO-1-
Gene: Hmox1  Location: Chr8:75820249-75827217 bp, + strand  Genetic Position: Chr8, 35.59 cM, cytoband C1
Alliance: Hmox1tm1Mlee page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:54684
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin cassette replaced exon 3 of the gene. Northern blots of liver RNA and Western blots of total liver protein from homozygous mutant mice showed no detectable transcript or protein, respectively, for the targeted gene. (J:54684)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 8 assay results
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hmox1 Mutation:  35 strains or lines available
References
Original:  J:54684 Yet SF, et al., Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice. J Clin Invest. 1999 Apr;103(8):R23-9
All:  45 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory