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Neurl3 Gene Detail
Summary
  • Symbol
    Neurl3
  • Name
    neuralized E3 ubiquitin protein ligase 3
  • Synonyms
    2010300P06Rik, Lincr
  • Feature Type
    protein coding gene
  • IDs
    MGI:2429944
    NCBI Gene: 214854
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:36303683-36313755 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 15.18 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    473 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2429944
 protein coding gene Chr1:36303678-36313760 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015919
 protein coding gene Chr1:34779304-34791637 (-)
A/J MGP_AJ_G0015903
 protein coding gene Chr1:33851996-33862020 (-)
AKR/J MGP_AKRJ_G0015858
 protein coding gene Chr1:34337311-34347390 (-)
BALB/cJ MGP_BALBcJ_G0015857
 protein coding gene Chr1:33546810-33556662 (-)
C3H/HeJ MGP_C3HHeJ_G0015690
 protein coding gene Chr1:34520617-34530624 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016310
 protein coding gene Chr1:36359115-36368927 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014032
 protein coding gene Chr1:30916782-30926460 (-)
CAST/EiJ MGP_CASTEiJ_G0015271
 protein coding gene Chr1:34414896-34424812 (-)
CBA/J MGP_CBAJ_G0015662
 protein coding gene Chr1:37301823-37313342 (-)
DBA/2J MGP_DBA2J_G0015763
 protein coding gene Chr1:33195393-33205353 (-)
FVB/NJ MGP_FVBNJ_G0015765
 protein coding gene Chr1:32712918-32722723 (-)
LP/J MGP_LPJ_G0015833
 protein coding gene Chr1:35150471-35160326 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015785
 protein coding gene Chr1:39541205-39552177 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016357
 protein coding gene Chr1:34356246-34367585 (-)
PWK/PhJ MGP_PWKPhJ_G0015054
 protein coding gene Chr1:32935617-32945736 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014836
 protein coding gene Chr1:34315870-34325643 (-)
WSB/EiJ MGP_WSBEiJ_G0015333
 protein coding gene Chr1:34309979-34319884 (-)



Homology
more
  • Human Ortholog
    NEURL3, neuralized E3 ubiquitin protein ligase 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEURL3, neuralized E3 ubiquitin protein ligase 3
  • Synonyms
    LINCR, RNF132
  • Links
    NCBI Gene ID: 93082
    neXtProt AC: NX_Q96EH8
    UniProt: Q96EH8

  • Chr Location
    2q11.2; chr2:96497646-96508109 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display increased susceptibility to Riboviria infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    817
  • Tissues
    50
  • cDNA Data
    23
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 214854 NCBI Gene Model | MGI Sequence Detail 10073 C57BL/6J ±  kb
    transcript NM_153408 RefSeq | MGI Sequence Detail 2583 C57BL/6  
    polypeptide Q8CJC5 UniProt | EBI | MGI Sequence Detail 254 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 23

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1923780
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 8
      Gene Ontology 5
      Phenotypes 5
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:344834 Ning X, et al., Divergent expression of Neurl3 from hemogenic endothelial cells to hematopoietic stem progenitor cells during development. J Genet Genomics. 2023 Sep;50(9):661-675
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory