Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Krastm4Tyj Name: Kirsten rat sarcoma viral oncogene homolog; targeted mutation 4, Tyler Jacks MGI ID: MGI:2429948 Synonyms: caKRas, KR, Kras2tm14Tyj, Kras2tm4Tyj, KrasG12D, K-RasG12D, K-Ras(G12D)fl, K-RasL, KrasLox, K-rasLSL, KrasLSL-G12D, Lox-Stop-Lox-KrasG12D, LSL-K-ras G12D, LSL-K-rasG12D, LSL-Kras G12D, LSL-KrasG12D, LSL-KrasG12D Gene: Kras  Location: Chr6:145162425-145195965 bp, - strand  Genetic Position: Chr6, 77.37 cM, cytoband G2 Alliance: Krastm4Tyj page

Pancreatic tumors in Krastm4Tyj/Krastm4Tyj Trim33tm1Los/Trim33tm1Los Tg(Pdx1-cre)89.1Dam/0 and Krastm4Tyj/Krastm4Tyj Cdkn2atm4Rdp/Cdkn2atm4Rdp Tg(Pdx1-cre)89.1Dam/0 mice Show the 5 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:73445
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Conditional ready, Null/knockout) Mutations:    Insertion, Single point mutation   Mutation details: Glycine codon 12 was changed to aspartic acid (p.G12D) to encode an oncogenic form of the KRAS2 protein. A loxP site flanked STOP cassette was included upstream of the inserted Kras2 sequence, such that the mutant transcript would be expressed only after Cre-mediated recombination. (J:73445)

View phenotypes and curated references for all genotypes (concatenated display).

Key:

√ disease model   expected model not found

Models:

Human Diseases ht1 cn4 cn6 cn11 cn13 cn14 cn15 cn22 cn23 cn24 cn27 cn36 cn58 cn64 cn66 cn67 cn73 cn74 cn76 cn81 cn85 cn90 cn104 cn114 cn116 cn119 cn123 cn124 cn138 cn139 cn141 cn142 cn149 cn151 cn153 cn154 cn155 cn156 cn157 cn168 cn176 cn177 cn181 cn184 cn185 cn186 cn187 cn191 cn194 cn201 cn203 cn204 cn215 cn221 cn222 cn225 cn227 acute myeloid leukemia IDs acute myeloid leukemia       DOID:9119 DOID:9118 DOID:9171 ICD10CM:C92.0 ICD9CM:205.0 KEGG:05221 MESH:D015470 NCI:C3171 OMIM:601626 UMLS_CUI:C0023467 Close adenoma IDs adenoma       DOID:657 DOID:2655 MESH:D000236 NCI:C2855 NCI:C4196 UMLS_CUI:C0001430 UMLS_CUI:C0334389 Close √ arteriovenous malformations of the brain IDs arteriovenous malformations of the brain       DOID:0060688 ICD10CM:Q28.2 MESH:D002538 OMIM:108010 ORDO:46724 UMLS_CUI:C0007772 Close √ √ colorectal cancer IDs colorectal cancer       DOID:9256 ICD10CM:C18.9 KEGG:05210 MESH:D015179 NCI:C2956 NCI:C4978 OMIM:114500 UMLS_CUI:C0009404 UMLS_CUI:C0346629 Close √ √ endometriosis IDs endometriosis       DOID:289 EFO:0001065 ICD10CM:N80 ICD9CM:617 ICD9CM:617.9 MESH:D004715 NCI:C3014 UMLS_CUI:C0014175 Close √ granulosa cell tumor IDs granulosa cell tumor       DOID:2999 DOID:5333 MESH:D006106 NCI:C3070 NCI:C4205 UMLS_CUI:C0018206 UMLS_CUI:C0334401 Close √ √ intrahepatic cholangiocarcinoma IDs intrahepatic cholangiocarcinoma       DOID:4928 ICD10CM:C22.1 MESH:D018281 NCI:C35417 UMLS_CUI:C0345905 Close √ √ √ √ juvenile myelomonocytic leukemia IDs juvenile myelomonocytic leukemia       DOID:0050458 ICD10CM:C93.3 MESH:D054429 NCI:C9233 OMIM:607785 UMLS_CUI:C0349639 Close √ √ √ juvenile type testicular granulosa cell tumor IDs juvenile type testicular granulosa cell tumor       DOID:6032 DOID:5332 NCI:C39947 NCI:C4207 UMLS_CUI:C0334403 UMLS_CUI:C1515285 Close √ lung cancer IDs lung cancer       DOID:1324 DOID:13075 DOID:1322 DOID:9881 ICD10CM:C34.1 ICD10CM:C34.2 ICD10CM:C34.3 ICD9CM:162.3 ICD9CM:162.4 ICD9CM:162.5 ICD9CM:162.8 OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210 UMLS_CUI:C0024624 UMLS_CUI:C0153491 UMLS_CUI:C0153492 UMLS_CUI:C0153493 Close √ √ √ √ √ √ √ √ √ lung non-small cell carcinoma IDs lung non-small cell carcinoma       DOID:3908 EFO:0003060 KEGG:05223 MESH:D002289 NCI:C2926 UMLS_CUI:C0007131 Close √ √ malignant fibrous histiocytoma IDs malignant fibrous histiocytoma       DOID:1907 MESH:D051677 NCI:C4247 UMLS_CUI:C0334463 Close √ malignant peripheral nerve sheath tumor IDs malignant peripheral nerve sheath tumor       DOID:5940 MESH:D018319 NCI:C3798 UMLS_CUI:C0751690 Close √ neurofibromatosis 1 IDs neurofibromatosis 1       DOID:0111253 ICD10CM:Q85.01 MESH:D009456 NCI:C3273 OMIM:162200 ORDO:636 UMLS_CUI:C0027831 Close √ oral cavity cancer IDs oral cavity cancer       DOID:8618 DOID:0050627 DOID:8617 DOID:9049 DOID:9055 ICD10CM:C04 ICD10CM:C04.0 ICD10CM:C04.1 ICD9CM:144 ICD9CM:144.0 ICD9CM:144.1 ICD9CM:144.9 NCI:C9318 UMLS_CUI:C0153368 UMLS_CUI:C0153369 UMLS_CUI:C0496758 Close √ ovarian cancer IDs ovarian cancer       DOID:2394 DOID:0060070 DOID:2144 DOID:9595 ICD10CM:C56 ICD9CM:183.0 MESH:D010051 NCI:C4984 NCI:C7431 OMIM:167000 OMIM:607893 ORDO:213500 ORDO:213517 UMLS_CUI:C0919267 UMLS_CUI:C1140680 UMLS_CUI:C1299247 Close √ √ √ √ pancreatic carcinoma IDs pancreatic carcinoma       DOID:4905 EFO:0002618 NCI:C3850 OMIM:260350 UMLS_CUI:C0235974 Close √ √ √ √ √ √ √ √ √ pancreatic ductal adenocarcinoma IDs pancreatic ductal adenocarcinoma       DOID:3498 NCI:C9120 UMLS_CUI:C1335302 Close √ √ √ √ √ √ √ √ √ √ prostate cancer IDs prostate cancer       DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358 Close √ √ √ sarcoma IDs sarcoma       DOID:1115 DOID:3936 ICD10CM:C49 ICD9CM:171 ICD9CM:171.9 UMLS_CUI:C0153519 Close √ √ skin melanoma IDs skin melanoma       DOID:8923 DOID:0050609 DOID:10043 DOID:10046 DOID:10051 DOID:10052 DOID:10055 DOID:8922 ICD10CM:C43.9 ICD9CM:172 ICD9CM:172.0 ICD9CM:172.2 ICD9CM:172.4 ICD9CM:172.5 ICD9CM:172.9 MESH:D000096142 NCI:C3510 OMIM:608035 OMIM:612263 UMLS_CUI:C0151779 Close √ squamous cell carcinoma IDs squamous cell carcinoma       DOID:1749 DOID:5512 EFO:0000707 MESH:D002294 MESH:D018307 NCI:C2929 UMLS_CUI:C0007137 UMLS_CUI:C0751688 Close √ √ urinary bladder cancer IDs urinary bladder cancer       DOID:11054 DOID:5428 ICD10CM:C67 ICD9CM:188 ICD9CM:188.9 KEGG:05219 MESH:D001749 NCI:C2901 NCI:C9334 OMIM:109800 UMLS_CUI:C0005684 UMLS_CUI:C0005695 Close √

In Mice Carrying this Mutation:	86 assay results 13 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	51 anatomical structure(s)

List all tumor models in MMHCdb carrying Krastm4Tyj

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 12 strains available      Cell Lines: 0 lines available
Carrying any Kras Mutation:	90 strains or lines available

Original:	J:73445 Jackson EL, et al., Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev. 2001 Dec 15;15(24):3243-8
All:	1527 reference(s)