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Lamp3 Gene Detail
Summary
  • Symbol
    Lamp3
  • Name
    lysosomal-associated membrane protein 3
  • Synonyms
    1200002D17Rik, Cd208, DC-LAMP, TSC403
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441659
    NCBI Gene: 239739
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:19472131-19525115 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 12.17 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1196 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441659
 protein coding gene Chr16:19472128-19525125 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022632
 protein coding gene Chr16:16934713-16982694 (-)
A/J MGP_AJ_G0022594
 protein coding gene Chr16:16135379-16185984 (-)
AKR/J MGP_AKRJ_G0022569
 protein coding gene Chr16:16782263-16836234 (-)
BALB/cJ MGP_BALBcJ_G0022598
 protein coding gene Chr16:16289150-16340303 (-)
C3H/HeJ MGP_C3HHeJ_G0022363
 protein coding gene Chr16:16929884-16978868 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023049
 protein coding gene Chr16:17271374-17319481 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020566
 protein coding gene Chr16:16114059-16158877 (-)
CAST/EiJ MGP_CASTEiJ_G0021893
 protein coding gene Chr16:16902066-16962917 (-)
CBA/J MGP_CBAJ_G0022335
 protein coding gene Chr16:18013782-18063386 (-)
DBA/2J MGP_DBA2J_G0022467
 protein coding gene Chr16:16031336-16084595 (-)
FVB/NJ MGP_FVBNJ_G0022442
 protein coding gene Chr16:16094974-16150745 (-)
LP/J MGP_LPJ_G0022534
 protein coding gene Chr16:16704406-16757391 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022462
 protein coding gene Chr16:17666892-17738957 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023060
 protein coding gene Chr16:16697197-16759550 (-)
PWK/PhJ MGP_PWKPhJ_G0021634
 protein coding gene Chr16:16319102-16366721 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021463
 protein coding gene Chr16:16528942-16582088 (-)
WSB/EiJ MGP_WSBEiJ_G0021937
 protein coding gene Chr16:16712335-16764585 (-)



Homology
more
  • Human Ortholog
    LAMP3, lysosomal associated membrane protein 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LAMP3, lysosomal associated membrane protein 3
  • Synonyms
    CD208, DC LAMP, DC-LAMP, DCLAMP, LAMP, LAMP-3, TSC403
  • Links
    NCBI Gene ID: 27074
    neXtProt AC: NX_Q9UQV4
    UniProt: Q9UQV4

  • Chr Location
    3q27.1; chr3:183122215-183163839 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Under basal conditions, homozygous null mice display altered protein and lipid composition of pulmonary surfactant but normal viability and lung function. However, under conditions of experimental allergic asthma, mice show increased airway resistance and aggravated changes in BAL lipid composition.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    717
  • Tissues
    3
  • cDNA Data
    5
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 239739 NCBI Gene Model | MGI Sequence Detail 52985 C57BL/6J ±  kb
    transcript NM_177356 RefSeq | MGI Sequence Detail 3343 C57BL/6  
    polypeptide Q7TST5 UniProt | EBI | MGI Sequence Detail 411 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000001882 lysosome-associated membrane glycoprotein 3
      (term hierarchy)
    • InterPro Domains
      IPR002000 Lysosome-associated membrane glycoprotein
      IPR048528 Lysosome-associated membrane glycoprotein 2-like, luminal domains
    • GlyGen
      Q7TST5 1 site
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 5
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 8
      Gene Ontology 7
      Phenotypes 6
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:354192 He H, et al., PRDM3/16 regulate chromatin accessibility required for NKX2-1 mediated alveolar epithelial differentiation and function. Nat Commun. 2024 Sep 16;15(1):8112
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/19/2024
    MGI 6.24     		The Jackson Laboratory