Rab7b MGI Mouse Gene Detail - MGI:2442295 - RAB7B, member RAS oncogene family

Symbol

Rab7b
Name

RAB7B, member RAS oncogene family
Synonyms

5430435G22Rik, Rab7b

Feature Type

protein coding gene
IDs

MGI:2442295
NCBI Gene: 226421
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr1:131616433-131643177 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 57.18 cM
Mapping Data

1 experiment

SNPs within 2kb

875 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442295	protein coding gene	Chr1:131616412-131646288 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016457	protein coding gene	Chr1:135117053-135143412 (+)
A/J	MGP_AJ_G0016440	protein coding gene	Chr1:130127386-130154288 (+)
AKR/J	MGP_AKRJ_G0016405	protein coding gene	Chr1:133945224-133972173 (+)
BALB/cJ	MGP_BALBcJ_G0016400	protein coding gene	Chr1:130447076-130473353 (+)
C3H/HeJ	MGP_C3HHeJ_G0016226	protein coding gene	Chr1:134093451-134121095 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016861	protein coding gene	Chr1:140146688-140173000 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014575	protein coding gene	Chr1:123254791-123282021 (+)
CAST/EiJ	MGP_CASTEiJ_G0015806	protein coding gene	Chr1:133084721-133112283 (+)
CBA/J	MGP_CBAJ_G0016198	protein coding gene	Chr1:144932866-144959810 (+)
DBA/2J	MGP_DBA2J_G0016305	protein coding gene	Chr1:129087966-129114415 (+)
FVB/NJ	MGP_FVBNJ_G0016304	protein coding gene	Chr1:127714065-127741064 (+)
LP/J	MGP_LPJ_G0016376	protein coding gene	Chr1:136427031-136457634 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016329	protein coding gene	Chr1:150714448-150740573 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016897	protein coding gene	Chr1:133698538-133734321 (+)
PWK/PhJ	MGP_PWKPhJ_G0015592	protein coding gene	Chr1:128044095-128067953 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015379	protein coding gene	Chr1:132648515-132674742 (+)
WSB/EiJ	MGP_WSBEiJ_G0015868	protein coding gene	Chr1:133688376-133717345 (+)

Human Ortholog

RAB7B, RAB7B, member RAS oncogene family

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAB7B, RAB7B, member RAS oncogene family
Synonyms

RAB7
Links

HGNC:30513

NCBI Gene ID: 338382

neXtProt AC: NX_Q96AH8

UniProt: Q96AH8
Chr Location

1q32.1; chr1:205976740-206003461 (-) GRCh38

MGI Vertebrate Homology

Rab7b stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: RAB7B
Gene Tree

Rab7b

less

Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

2
Radiation induced

1
Targeted

2
Genomic Mutations

3 involving Rab7b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available

Mice homozygous for a null allele exhibit impaired dendritic cell migration with reduced number of small lysosomes per cell in LPS-exposed cells.

less

All GO Annotations

31
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

6

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rab7b

less

All Sequences

64
RefSeq

20
UniProt

4
CCDS

CCDS15272.1, CCDS78677.1

Ensembl

ENSMUSG00000052688 (Evidence)
NCBI Gene

226421

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052688	Ensembl Gene Model \| MGI Sequence Detail	26745	C57BL/6J	± kb
transcript	ENSMUST00000064679	Ensembl \| MGI Sequence Detail	4498	Not Applicable
polypeptide	ENSMUSP00000065456	Ensembl \| MGI Sequence Detail	199	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000013640 Ras-related protein Rab-7b

(term hierarchy)
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001806 Small GTPase

IPR005225 Small GTP-binding protein domain

less

All nucleic 6

cDNA 6

Microarray probesets 4

Summaries

All 32

Gene Ontology 9

Phenotypes 7
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:321707 Vestre K, et al., Rab7b regulates dendritic cell migration by linking lysosomes to the actomyosin cytoskeleton. J Cell Sci. 2021 Sep 15;134(18):jcs259221

TSS for Rab7b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8651	Chr1:131616408-131616472 (+)	7 bp
Tssr8652	Chr1:131616482-131616491 (+)	54 bp
Tssr8653	Chr1:131616509-131616522 (+)	83 bp
Tssr8654	Chr1:131624356-131624368 (+)	7,929 bp
Tssr8655	Chr1:131624395-131624406 (+)	7,968 bp
Tssr8656	Chr1:131640358-131640370 (+)	23,931 bp
Tssr8657	Chr1:131640453-131640463 (+)	24,025 bp
Tssr8658	Chr1:131640656-131640667 (+)	24,229 bp
Tssr8659	Chr1:131640834-131640849 (+)	24,409 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24