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Stk38 Gene Detail
Summary
  • Symbol
    Stk38
  • Name
    serine/threonine kinase 38
  • Synonyms
    5830476G13Rik, 9530097A09Rik, Ndr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442572
    NCBI Gene: 106504
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:29189854-29226969 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 15.03 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    131 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442572
 protein coding gene Chr17:29189854-29226979 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023455
 protein coding gene Chr17:28459396-28497443 (-)
A/J MGP_AJ_G0023413
 protein coding gene Chr17:27479895-27519985 (-)
AKR/J MGP_AKRJ_G0023378
 protein coding gene Chr17:27704124-27748703 (-)
BALB/cJ MGP_BALBcJ_G0023418
 protein coding gene Chr17:27762343-27800197 (-)
C3H/HeJ MGP_C3HHeJ_G0023179
 protein coding gene Chr17:28094135-28134284 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023860
 protein coding gene Chr17:29585460-29625952 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021335
 protein coding gene Chr17:24831216-24867347 (-)
CAST/EiJ MGP_CASTEiJ_G0022680
 protein coding gene Chr17:28071918-28112156 (-)
CBA/J MGP_CBAJ_G0023153
 protein coding gene Chr17:30668812-30717549 (-)
DBA/2J MGP_DBA2J_G0023284
 protein coding gene Chr17:27025871-27062989 (-)
FVB/NJ MGP_FVBNJ_G0023254
 protein coding gene Chr17:26852887-26890498 (-)
LP/J MGP_LPJ_G0023362
 protein coding gene Chr17:28706124-28751740 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023272
 protein coding gene Chr17:30045924-30087654 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023902
 protein coding gene Chr17:28157423-28197416 (-)
PWK/PhJ MGP_PWKPhJ_G0022430
 protein coding gene Chr17:25854383-25892640 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022248
 protein coding gene Chr17:26163410-26202405 (-)
WSB/EiJ MGP_WSBEiJ_G0022742
 protein coding gene Chr17:28131054-28170628 (-)



Homology
more
  • Human Ortholog
    STK38, serine/threonine kinase 38
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STK38, serine/threonine kinase 38
  • Synonyms
    NDR, NDR1
  • Links
    NCBI Gene ID: 11329
    neXtProt AC: NX_Q15208
    UniProt: Q15208

  • Chr Location
    6p21.31; chr6:36493892-36547479 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 5 alleles in 5 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to bacterial infection and altered TLR9-activated inflammatory responses. Mice homozygous for a different knock-out allele exhibit mislocalization of opsin, increased apoptosis and proliferation of photoreceptors in the inner nuclear layer and disrupted localization of amacrine cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    885
  • Tissues
    146
  • cDNA Data
    16
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024006 Ensembl Gene Model | MGI Sequence Detail 37116 C57BL/6J ±  kb
    transcript ENSMUST00000009138 Ensembl | MGI Sequence Detail 3351 Not Applicable  
    polypeptide ENSMUSP00000009138 Ensembl | MGI Sequence Detail 465 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 17
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1924472, MGI:2146777
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 20
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory