Mpzl3 MGI Mouse Gene Detail - MGI:2442647 - myelin protein zero-like 3

Symbol

Mpzl3
Name

myelin protein zero-like 3
Synonyms

5430427F17Rik, A530065I17Rik, rc, ruf

Feature Type

protein coding gene
IDs

MGI:2442647
NCBI Gene: 319742
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr9:44966484-44988734 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 24.84 cM
Mapping Data

7 experiments

SNPs within 2kb

758 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442647	protein coding gene	Chr9:44966479-44988735 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034728	protein coding gene	Chr9:43595421-43618978 (+)
A/J	MGP_AJ_G0034709	protein coding gene	Chr9:42380150-42402383 (+)
AKR/J	MGP_AKRJ_G0034636	protein coding gene	Chr9:43255258-43277514 (+)
BALB/cJ	MGP_BALBcJ_G0034700	protein coding gene	Chr9:42112026-42134257 (+)
C3H/HeJ	MGP_C3HHeJ_G0034411	protein coding gene	Chr9:43706491-43730590 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035221	protein coding gene	Chr9:44875400-44897642 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032136	protein coding gene	Chr9:41931340-41953757 (+)
CAST/EiJ	MGP_CASTEiJ_G0033733	protein coding gene	Chr9:43571975-43594178 (+)
CBA/J	MGP_CBAJ_G0034383	protein coding gene	Chr9:46523494-46545746 (+)
DBA/2J	MGP_DBA2J_G0034542	protein coding gene	Chr9:42269174-42291405 (+)
FVB/NJ	MGP_FVBNJ_G0034483	protein coding gene	Chr9:41526258-41548982 (+)
LP/J	MGP_LPJ_G0034623	protein coding gene	Chr9:43891191-43916639 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034527	protein coding gene	Chr9:48346939-48369172 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035242	protein coding gene	Chr9:43173412-43195747 (+)
PWK/PhJ	MGP_PWKPhJ_G0033438	protein coding gene	Chr9:42155276-42178134 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033274	protein coding gene	Chr9:43462678-43485024 (+)
WSB/EiJ	MGP_WSBEiJ_G0033846	protein coding gene	Chr9:43200428-43222665 (+)

Human Ortholog

MPZL3, myelin protein zero like 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MPZL3, myelin protein zero like 3
Links

HGNC:27279

NCBI Gene ID: 196264

neXtProt AC: NX_Q6UWV2

UniProt: Q6UWV2
Chr Location

11q23.3; chr11:118226690-118252365 (-) GRCh38

MGI Vertebrate Homology

Mpzl3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MPZL3
Gene Tree

Mpzl3

Diseases

1 with human MPZL3 associations

				Human Disease	Mouse Models
				lung cancer IDs lung cancer DOID:1324 DOID:13075 DOID:1322 DOID:9881 ICD10CM:C34.1 ICD10CM:C34.2 ICD10CM:C34.3 ICD9CM:162.3 ICD9CM:162.4 ICD9CM:162.5 ICD9CM:162.8 OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210 UMLS_CUI:C0024624 UMLS_CUI:C0153491 UMLS_CUI:C0153492 UMLS_CUI:C0153493

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

89 phenotypes from 4 alleles in 5 genetic backgrounds
2 images
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Endonuclease-mediated

3
Gene trapped

5
Spontaneous

3
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a spontaneous allele have a rough coat that becomes brittle and oily with age, and display stunted growth, cyclic and progressive hair loss, hyperplastic epidermis, abnormal hair follicles, myocardial degeneration, and reduced collagen and elastin content in the skin and heart.

less

All GO Annotations

5
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

7
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mpzl3

less

All Sequences

40
RefSeq

2
UniProt

2
CCDS

CCDS40605.1, CCDS52781.1

Ensembl

ENSMUSG00000070305 (Evidence)
NCBI Gene

319742

			Length	Strain/Species	Flank
genomic	ENSMUSG00000070305	Ensembl Gene Model \| MGI Sequence Detail	22251	C57BL/6J	± kb
transcript	ENSMUST00000114664	Ensembl \| MGI Sequence Detail	3424	Not Applicable
polypeptide	ENSMUSP00000110312	Ensembl \| MGI Sequence Detail	237	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000010556 myelin protein zero-like protein 3

(term hierarchy)
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR013106 Immunoglobulin V-set domain

IPR000920 Myelin P0 protein-related
GlyGen

Q3V3F6 1 site, 1 N-linked glycan (1 site)

less

All nucleic 7

cDNA 7

Microarray probesets 2

less

MGD-MRK-13802, MGD-MRK-14253, MGI:1918661, MGI:97880, MGI:98207

Summaries

All 38

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 19
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Mpzl3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84719	Chr9:44966464-44966493 (+)	-5 bp
Tssr84720	Chr9:44966509-44966523 (+)	32 bp
Tssr84721	Chr9:44966526-44966541 (+)	50 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24