About   Help   FAQ
Cdc14a Gene Detail
Summary
  • Symbol
    Cdc14a
  • Name
    CDC14 cell division cycle 14A
  • Synonyms
    A830059A17Rik, Cdc14, CDC14a1, CDC14A2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442676
    NCBI Gene: 229776
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:116066202-116222390 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 50.24 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4661 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442676
 protein coding gene Chr3:116066202-116222394 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027809
 protein coding gene Chr3:118163236-118322848 (-)
A/J MGP_AJ_G0027767
 protein coding gene Chr3:114288244-114448765 (-)
AKR/J MGP_AKRJ_G0027733
 protein coding gene Chr3:117189092-117349218 (-)
BALB/cJ MGP_BALBcJ_G0027779
 protein coding gene Chr3:114138497-114293382 (-)
C3H/HeJ MGP_C3HHeJ_G0027510
 protein coding gene Chr3:117544690-117702416 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028225
 protein coding gene Chr3:122499598-122662859 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025564
 protein coding gene Chr3:109985857-110140749 (-)
CAST/EiJ MGP_CASTEiJ_G0026966
 protein coding gene Chr3:116824221-116988117 (-)
CBA/J MGP_CBAJ_G0027485
 protein coding gene Chr3:126677249-126857694 (-)
DBA/2J MGP_DBA2J_G0027626
 protein coding gene Chr3:113531249-113685632 (-)
FVB/NJ MGP_FVBNJ_G0027594
 protein coding gene Chr3:111171736-111324262 (-)
LP/J MGP_LPJ_G0027736
 protein coding gene Chr3:119707172-119873632 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027624
 protein coding gene Chr3:134044688-134220069 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028281
 protein coding gene Chr3:116722181-116880622 (-)
PWK/PhJ MGP_PWKPhJ_G0026692
 protein coding gene Chr3:113172323-113326344 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026514
 protein coding gene Chr3:114736241-114926273 (-)
WSB/EiJ MGP_WSBEiJ_G0027046
 protein coding gene Chr3:117410811-117574738 (-)



Homology
more
  • Human Ortholog
    CDC14A, cell division cycle 14A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDC14A, cell division cycle 14A
  • Synonyms
    cdc14, DFNB105, DFNB32, DFNB35, hCDC14
  • Links
    NCBI Gene ID: 8556
    neXtProt AC: NX_Q9UNH5
    UniProt: Q9UNH5

  • Chr Location
    1p21.2; chr1:100345001-100520277 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cdc14a mouse models; 1 with human CDC14A associations

Human Disease Mouse Models
      
IDs
 View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 6 alleles in 5 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutations of this gene, including a single amino acid substitution that ablates phosphatase activity, result in incomplete preweaning lethality, profound deafness and male infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    873
  • Tissues
    159
  • cDNA Data
    43
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 229776 NCBI Gene Model | MGI Sequence Detail 156189 C57BL/6J ±  kb
    transcript NM_001080818 RefSeq | MGI Sequence Detail 4511 C57BL/6  
    polypeptide Q6GQT0 UniProt | EBI | MGI Sequence Detail 603 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000005184 dual specificity protein phosphatase CDC14A
      (term hierarchy)
    • EC
      3.1.3.16, 3.1.3.48
    • InterPro Domains
      IPR044506 Dual-specificity phosphatase CDC14, C-terminal
      IPR020422 Dual specificity protein phosphatase domain
      IPR029260 Dual specificity/tyrosine protein phosphatase, N-terminal
      IPR050561 Protein Tyrosine Phosphatase
      IPR016130 Protein-tyrosine phosphatase, active site
      IPR003595 Protein-tyrosine phosphatase, catalytic
      IPR029021 Protein-tyrosine phosphatase-like
      IPR000387 Tyrosine-specific protein phosphatases domain
    • GlyGen
      Q6GQT0 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 45
      cDNA 43
      Primer pair 1
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 5
      Diseases 2
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory