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Dnajc27 Gene Detail
Summary
  • Symbol
    Dnajc27
  • Name
    DnaJ heat shock protein family (Hsp40) member C27
  • Synonyms
    C330021A05Rik, Rabj, Rbj
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443036
    NCBI Gene: 217378
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:4132583-4160606 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 1.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    789 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443036
 protein coding gene Chr12:4132569-4174140 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019563
 protein coding gene Chr12:941021-968999 (+)
A/J MGP_AJ_G0019530
 protein coding gene Chr12:961525-993648 (+)
AKR/J MGP_AKRJ_G0019500
 protein coding gene Chr12:1114669-1144723 (+)
BALB/cJ MGP_BALBcJ_G0019505
 protein coding gene Chr12:989160-1017394 (+)
C3H/HeJ MGP_C3HHeJ_G0019311
 protein coding gene Chr12:892327-924944 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019954
 protein coding gene Chr12:960282-990311 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017579
 protein coding gene Chr12:869892-902299 (+)
CAST/EiJ MGP_CASTEiJ_G0018866
 protein coding gene Chr12:966964-998633 (+)
CBA/J MGP_CBAJ_G0019282
 protein coding gene Chr12:1211264-1242233 (+)
DBA/2J MGP_DBA2J_G0019395
 protein coding gene Chr12:903320-931927 (+)
FVB/NJ MGP_FVBNJ_G0019385
 protein coding gene Chr12:927997-957154 (+)
LP/J MGP_LPJ_G0019466
 protein coding gene Chr12:959969-992082 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019419
 protein coding gene Chr12:1018278-1048651 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019993
 protein coding gene Chr12:896509-926532 (+)
PWK/PhJ MGP_PWKPhJ_G0018632
 protein coding gene Chr12:925581-954301 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018423
 protein coding gene Chr12:966484-996547 (+)
WSB/EiJ MGP_WSBEiJ_G0018918
 protein coding gene Chr12:924808-952817 (+)



Homology
more
  • Human Ortholog
    DNAJC27, DnaJ heat shock protein family (Hsp40) member C27
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNAJC27, DnaJ heat shock protein family (Hsp40) member C27
  • Synonyms
    RabJS, RBJ
  • Links
    NCBI Gene ID: 51277
    neXtProt AC: NX_Q9NZQ0
    UniProt: Q9NZQ0

  • Chr Location
    2p23.3; chr2:24943636-24972094 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit decreased incidence, multiplicity and tumor burden in an AOM/DSS-induced colonic carcinogenesis model.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    66
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020657 Ensembl Gene Model | MGI Sequence Detail 28024 C57BL/6J ±  kb
    transcript ENSMUST00000020986 Ensembl | MGI Sequence Detail 4698 Not Applicable  
    polypeptide ENSMUSP00000020986 Ensembl | MGI Sequence Detail 273 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 66
      cDNA 66

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144867
    References
    more
    • Summaries
      All 30
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory