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Map3k20 Gene Detail
Summary
  • Symbol
    Map3k20
  • Name
    mitogen-activated protein kinase kinase kinase 20
  • Synonyms
    B230120H23Rik, MLTKalpha, MLTKbeta, Zak
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443258
    NCBI Gene: 65964
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:72115981-72272954 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 43.11 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4166 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443258
 protein coding gene Chr2:72115970-72272954 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025829
 protein coding gene Chr2:72464758-72626591 (+)
A/J MGP_AJ_G0025807
 protein coding gene Chr2:69621194-69778236 (+)
AKR/J MGP_AKRJ_G0025775
 protein coding gene Chr2:71556526-71715874 (+)
BALB/cJ MGP_BALBcJ_G0025801
 protein coding gene Chr2:69829591-69990505 (+)
C3H/HeJ MGP_C3HHeJ_G0025561
 protein coding gene Chr2:71743963-71902990 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026248
 protein coding gene Chr2:74648286-74809415 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023651
 protein coding gene Chr2:66855818-67018431 (+)
CAST/EiJ MGP_CASTEiJ_G0025025
 protein coding gene Chr2:71951540-72113111 (+)
CBA/J MGP_CBAJ_G0025542
 protein coding gene Chr2:77378133-77545515 (+)
DBA/2J MGP_DBA2J_G0025673
 protein coding gene Chr2:69249799-69407163 (+)
FVB/NJ MGP_FVBNJ_G0025635
 protein coding gene Chr2:68659021-68817783 (+)
LP/J MGP_LPJ_G0025761
 protein coding gene Chr2:72348639-72511714 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025666
 protein coding gene Chr2:79340284-79502583 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026305
 protein coding gene Chr2:71629653-71789354 (+)
PWK/PhJ MGP_PWKPhJ_G0024766
 protein coding gene Chr2:69136019-69294763 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024574
 protein coding gene Chr2:71833493-71995311 (+)
WSB/EiJ MGP_WSBEiJ_G0025093
 protein coding gene Chr2:72081894-72245590 (+)



Homology
more
  • Human Ortholog
    MAP3K20, mitogen-activated protein kinase kinase kinase 20
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP3K20, mitogen-activated protein kinase kinase kinase 20
  • Synonyms
    AZK, CNM6, MLK7, mlklak, MLT, MLTK, MLTKalpha, MLTKbeta, MRK, pk, SFMMP, ZAK
  • Links
    NCBI Gene ID: 51776
    neXtProt AC: NX_Q9NYL2
    UniProt: Q9NYL2

  • Chr Location
    2q31.1; chr2:173075435-173268015 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Map3k20 mouse models; 1 with human MAP3K20 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 1 genetic background
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete lethality at E9.5 with growth retardation. Mice homozygous for an allele lacking the SAM domain exhibit low penetrant unilateral complex hindlimb duplication phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    65
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    24
  • cDNA Data
    11
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004085 Ensembl Gene Model | MGI Sequence Detail 156974 C57BL/6J ±  kb
    transcript ENSMUST00000090824 Ensembl | MGI Sequence Detail 3334 Not Applicable  
    polypeptide ENSMUSP00000088334 Ensembl | MGI Sequence Detail 802 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000010457 mitogen-activated protein kinase kinase kinase 20
      (term hierarchy)
    • EC
      2.7.11.25
    • InterPro Domains
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR050167 Serine/threonine-protein kinase
      IPR008271 Serine/threonine-protein kinase, active site
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR001660 Sterile alpha motif domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
    • GlyGen
      Q9ESL4 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 11
      Primer pair 5
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1931274, MGI:2139236
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 10
      Phenotypes 26
    • Earliest
      J:21477 Zwacka RM, et al., The glomerulosclerosis gene Mpv17 encodes a peroxisomal protein producing reactive oxygen species. EMBO J. 1994 Nov 1;13(21):5129-34
    • Latest
      J:349727 Xi J, et al., Initiation of a ZAKalpha-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L. Cell Rep. 2024 Apr 23;43(4):113998
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory