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Rtbdn Gene Detail
Summary
  • Symbol
    Rtbdn
  • Name
    retbindin
  • Synonyms
    A330096I21Rik, MGC:31644, MGC:38683, MGC:38855
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443686
    NCBI Gene: 234542
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:85673620-85683232 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 41.37 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    292 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443686
 protein coding gene Chr8:85672880-85683235 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033881
 protein coding gene Chr8:85889065-85899547 (+)
A/J MGP_AJ_G0033864
 protein coding gene Chr8:82493579-82503172 (+)
AKR/J MGP_AKRJ_G0033790
 protein coding gene Chr8:84938804-84948286 (+)
BALB/cJ MGP_BALBcJ_G0033857
 protein coding gene Chr8:82621424-82635389 (+)
C3H/HeJ MGP_C3HHeJ_G0033567
 protein coding gene Chr8:85561531-85573046 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034377
 protein coding gene Chr8:89172865-89183310 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031318
 protein coding gene Chr8:76291373-76301983 (+)
CAST/EiJ MGP_CASTEiJ_G0032897
 protein coding gene Chr8:84996551-85006023 (+)
CBA/J MGP_CBAJ_G0033543
 protein coding gene Chr8:92193421-92203019 (+)
DBA/2J MGP_DBA2J_G0033696
 protein coding gene Chr8:82134161-82143945 (+)
FVB/NJ MGP_FVBNJ_G0033644
 protein coding gene Chr8:81085412-81096741 (+)
LP/J MGP_LPJ_G0033788
 protein coding gene Chr8:85991449-86000959 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033686
 protein coding gene Chr8:94757394-94768124 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034394
 protein coding gene Chr8:84927092-84936534 (+)
PWK/PhJ MGP_PWKPhJ_G0032601
 protein coding gene Chr8:81381131-81390746 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032437
 protein coding gene Chr8:83740607-83750115 (+)
WSB/EiJ MGP_WSBEiJ_G0033010
 protein coding gene Chr8:85357837-85369042 (+)



Homology
more
  • Human Ortholog
    RTBDN, retbindin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RTBDN, retbindin
  • Links
    NCBI Gene ID: 83546
    neXtProt AC: NX_Q9BSG5
    UniProt: Q9BSG5

  • Chr Location
    19p13.13; chr19:12825478-12835428 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted inactivation of this gene reduces flavin levels in the neural retina and leads to progressive and dose-dependent retinal photoreceptor degeneration of both rods and cones.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    741
  • Tissues
    32
  • cDNA Data
    24
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048617 Ensembl Gene Model | MGI Sequence Detail 9613 C57BL/6J ±  kb
    transcript ENSMUST00000121880 Ensembl | MGI Sequence Detail 1223 Not Applicable  
    polypeptide ENSMUSP00000113982 Ensembl | MGI Sequence Detail 247 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 25

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2384578
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 43
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory