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Nyap1 Gene Detail
Summary
  • Symbol
    Nyap1
  • Name
    neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1
  • Synonyms
    6430598A04Rik, Nyap1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443880
    NCBI Gene: 243300
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:137729144-137739430 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 76.62 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    208 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443880
 protein coding gene Chr5:137728161-137739869 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030241
 protein coding gene Chr5:142515833-142530081 (-)
A/J MGP_AJ_G0030209
 protein coding gene Chr5:136302823-136314561 (-)
AKR/J MGP_AKRJ_G0030142
 protein coding gene Chr5:140729218-140743170 (-)
BALB/cJ MGP_BALBcJ_G0030219
 protein coding gene Chr5:137679641-137701823 (-)
C3H/HeJ MGP_C3HHeJ_G0029935
 protein coding gene Chr5:141395043-141406754 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030671
 protein coding gene Chr5:147783765-147797229 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027889
 protein coding gene Chr5:130534610-130547077 (-)
CAST/EiJ MGP_CASTEiJ_G0029345
 protein coding gene Chr5:140786076-140797662 (-)
CBA/J MGP_CBAJ_G0029905
 protein coding gene Chr5:153667496-153679194 (-)
DBA/2J MGP_DBA2J_G0030056
 protein coding gene Chr5:136202011-136213556 (-)
FVB/NJ MGP_FVBNJ_G0030011
 protein coding gene Chr5:135405755-135417372 (-)
LP/J MGP_LPJ_G0030145
 protein coding gene Chr5:142998828-143010848 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030043
 protein coding gene Chr5:156469695-156482729 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030712
 protein coding gene Chr5:140586766-140599250 (-)
PWK/PhJ MGP_PWKPhJ_G0029058
 protein coding gene Chr5:135292748-135304955 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028894
 protein coding gene Chr5:138155375-138166998 (-)
WSB/EiJ MGP_WSBEiJ_G0029418
 protein coding gene Chr5:141316047-141327429 (-)



Homology
more
  • Human Ortholog
    NYAP1, neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NYAP1, neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1
  • Synonyms
    C7orf51
  • Links
    NCBI Gene ID: 222950
    neXtProt AC: NX_Q6ZVC0
    UniProt: Q6ZVC0

  • Chr Location
    7q22.1; chr7:100483927-100494802 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Triple KO of Nyap1, Nyap2 and Myo16 results in decreased brain weight and cortex and striatum size and reduced neurite length in cortical neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    858
  • Tissues
    40
  • cDNA Data
    8
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 243300 NCBI Gene Model | MGI Sequence Detail 10287 C57BL/6J ±  kb
transcript NM_001347505 RefSeq | MGI Sequence Detail 3501 C57BL/6  
polypeptide Q6PFX7 UniProt | EBI | MGI Sequence Detail 833 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000031533 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1
    (term hierarchy)
  • InterPro Domains
    IPR026722 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1/2
    IPR029353 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter, C-terminal domain
    IPR039482 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter, N-terminal
  • GlyGen
    Q6PFX7 2 sites, 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 9
    cDNA 8
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 25
    Developmental Gene Expression 4
    Gene Ontology 2
    Phenotypes 6
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:321979 Kurz J, et al., Notch signaling is a novel regulator of visceral smooth muscle cell differentiation in the murine ureter. Development. 2022 Feb 15;149(4):dev199735
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory