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Map3k13 Gene Detail
Summary
  • Symbol
    Map3k13
  • Name
    mitogen-activated protein kinase kinase kinase 13
  • Synonyms
    C130026N12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444243
    NCBI Gene: 71751
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:21643923-21752189 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 12.92 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3157 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444243
 protein coding gene Chr16:21613096-21752189 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022662
 protein coding gene Chr16:19346620-19392482 (+)
A/J MGP_AJ_G0022624
 protein coding gene Chr16:18415522-18455366 (+)
AKR/J MGP_AKRJ_G0022599
 protein coding gene Chr16:19188050-19228062 (+)
BALB/cJ MGP_BALBcJ_G0022628
 protein coding gene Chr16:18613960-18654224 (+)
C3H/HeJ MGP_C3HHeJ_G0022393
 protein coding gene Chr16:19288070-19330893 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023079
 protein coding gene Chr16:19749486-19794690 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020597
 protein coding gene Chr16:19119708-19158792 (+)
CAST/EiJ MGP_CASTEiJ_G0021923
 protein coding gene Chr16:19276120-19315344 (+)
CBA/J MGP_CBAJ_G0022365
 protein coding gene Chr16:20574613-20617300 (+)
DBA/2J MGP_DBA2J_G0022497
 protein coding gene Chr16:18400836-18441279 (+)
FVB/NJ MGP_FVBNJ_G0022472
 protein coding gene Chr16:18371424-18411046 (+)
LP/J MGP_LPJ_G0022564
 protein coding gene Chr16:19093382-19141460 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022492
 protein coding gene Chr16:20170888-20217970 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023090
 protein coding gene Chr16:19131737-19171462 (+)
PWK/PhJ MGP_PWKPhJ_G0021663
 protein coding gene Chr16:18634711-18675557 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021493
 protein coding gene Chr16:18912895-18956190 (+)
WSB/EiJ MGP_WSBEiJ_G0021966
 protein coding gene Chr16:19095053-19141108 (+)



Homology
more
  • Human Ortholog
    MAP3K13, mitogen-activated protein kinase kinase kinase 13
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP3K13, mitogen-activated protein kinase kinase kinase 13
  • Synonyms
    LZK, MEKK13, MLK
  • Links
    NCBI Gene ID: 9175
    neXtProt AC: NX_O43283
    UniProt: O43283

  • Chr Location
    3q27.2; chr3:185282941-185489094 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable, fertile and grossly normal with no overt developmental defect in cerebellar formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    745
  • Tissues
    18
  • cDNA Data
    6
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 71751 NCBI Gene Model | MGI Sequence Detail 108267 C57BL/6J ±  kb
transcript NM_172821 RefSeq | MGI Sequence Detail 6709 C57BL/6  
polypeptide Q1HKZ5 UniProt | EBI | MGI Sequence Detail 959 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000010132 mitogen-activated protein kinase kinase kinase 13
    (term hierarchy)
  • EC
    2.7.11.25
  • InterPro Domains
    IPR017419 Mitogen-activated protein kinase kinase kinase 12/13
    IPR027258 Mitogen-activated protein kinase kinase kinase 13
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR050167 Serine/threonine-protein kinase
    IPR008271 Serine/threonine-protein kinase, active site
    IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 1
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory