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Mapk4 Gene Detail
Summary
  • Symbol
    Mapk4
  • Name
    mitogen-activated protein kinase 4
  • Synonyms
    A330097D03Rik, Erk3-related, p63Mapk
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444559
    NCBI Gene: 225724
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:74061557-74198430 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 50.31 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5088 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444559
 protein coding gene Chr18:74061557-74198643 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024552
 protein coding gene Chr18:74527057-74669151 (-)
A/J MGP_AJ_G0024519
 protein coding gene Chr18:71283462-71420838 (-)
AKR/J MGP_AKRJ_G0024490
 protein coding gene Chr18:73393781-73533443 (-)
BALB/cJ MGP_BALBcJ_G0024519
 protein coding gene Chr18:71450247-71591785 (-)
C3H/HeJ MGP_C3HHeJ_G0024287
 protein coding gene Chr18:73478648-73625006 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024965
 protein coding gene Chr18:76485641-76631488 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022396
 protein coding gene Chr18:70385615-70522742 (-)
CAST/EiJ MGP_CASTEiJ_G0023760
 protein coding gene Chr18:73662873-73805281 (-)
CBA/J MGP_CBAJ_G0024256
 protein coding gene Chr18:79094532-79251758 (-)
DBA/2J MGP_DBA2J_G0024386
 protein coding gene Chr18:70876270-71015076 (-)
FVB/NJ MGP_FVBNJ_G0024352
 protein coding gene Chr18:70221050-70357775 (-)
LP/J MGP_LPJ_G0024470
 protein coding gene Chr18:74403385-74547523 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024382
 protein coding gene Chr18:80563614-80706406 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025013
 protein coding gene Chr18:73515995-73660390 (-)
PWK/PhJ MGP_PWKPhJ_G0023504
 protein coding gene Chr18:71239394-71381150 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023309
 protein coding gene Chr18:73673648-73821915 (-)
WSB/EiJ MGP_WSBEiJ_G0023823
 protein coding gene Chr18:73475786-73620922 (-)



Homology
more
  • Human Ortholog
    MAPK4, mitogen-activated protein kinase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAPK4, mitogen-activated protein kinase 4
  • Synonyms
    ERK-4, ERK4, p63-MAPK, p63MAPK, PRKM4
  • Links
    NCBI Gene ID: 5596
    neXtProt AC: NX_P31152
    UniProt: P31152

  • Chr Location
    18q21.1-q21.2; chr18:50559612-50731826 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    11 phenotype references
Mice homozygous for a knock-out allele are viabel and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    790
  • Tissues
    59
  • cDNA Data
    23
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024558 Ensembl Gene Model | MGI Sequence Detail 136874 C57BL/6J ±  kb
transcript ENSMUST00000091851 Ensembl | MGI Sequence Detail 4594 Not Applicable  
polypeptide ENSMUSP00000089462 Ensembl | MGI Sequence Detail 583 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 30
    cDNA 23
    Primer pair 2
    Other 5

    Microarray probesets 2
References
more
  • Summaries
    All 41
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:37168 Garcia JI, et al., Isolation of a cDNA encoding the rat MAP-kinase homolog of human p63mapk. Mamm Genome. 1996 Nov;7(11):810-4
  • Latest
    J:336925 Huang H, et al., MAP4K4 is involved in the neuronal development of retinal photoreceptors. Exp Eye Res. 2023 Jun 7;233:109524
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory