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Arhgap1 Gene Detail
Summary
  • Symbol
    Arhgap1
  • Name
    Rho GTPase activating protein 1
  • Synonyms
    B230365D05Rik, Cdc42GAP, p50rhoGAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445003
    NCBI Gene: 228359
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:91480463-91502670 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 50.63 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    610 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445003
 protein coding gene Chr2:91480205-91502671 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026154
 protein coding gene Chr2:92999444-93028174 (+)
A/J MGP_AJ_G0026115
 protein coding gene Chr2:89269477-89292028 (+)
AKR/J MGP_AKRJ_G0026096
 protein coding gene Chr2:91737909-91760439 (+)
BALB/cJ MGP_BALBcJ_G0026124
 protein coding gene Chr2:89453445-89475986 (+)
C3H/HeJ MGP_C3HHeJ_G0025875
 protein coding gene Chr2:92020424-92043591 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026575
 protein coding gene Chr2:96252167-96276724 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023966
 protein coding gene Chr2:85766991-85790017 (+)
CAST/EiJ MGP_CASTEiJ_G0025340
 protein coding gene Chr2:92569537-92592911 (+)
CBA/J MGP_CBAJ_G0025853
 protein coding gene Chr2:99556192-99578786 (+)
DBA/2J MGP_DBA2J_G0025989
 protein coding gene Chr2:88872143-88894595 (+)
FVB/NJ MGP_FVBNJ_G0025952
 protein coding gene Chr2:87970914-87993362 (+)
LP/J MGP_LPJ_G0026093
 protein coding gene Chr2:93216765-93239550 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025978
 protein coding gene Chr2:102575210-102599089 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026629
 protein coding gene Chr2:91811391-91835265 (+)
PWK/PhJ MGP_PWKPhJ_G0025075
 protein coding gene Chr2:88604394-88628087 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024876
 protein coding gene Chr2:91392407-91413678 (+)
WSB/EiJ MGP_WSBEiJ_G0025407
 protein coding gene Chr2:92411433-92434322 (+)



Homology
more
  • Human Ortholog
    ARHGAP1, Rho GTPase activating protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGAP1, Rho GTPase activating protein 1
  • Synonyms
    CDC42GAP, p50rhoGAP, RHOGAP, RHOGAP1
  • Links
    NCBI Gene ID: 392
    neXtProt AC: NX_Q07960
    UniProt: Q07960

  • Chr Location
    11p11.2; chr11:46677080-46700619 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    2 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display incomplete penetrance of postnatal lethality, increased apoptosis, and growth retardation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    140
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 228359 NCBI Gene Model | MGI Sequence Detail 22208 C57BL/6J ±  kb
    transcript NM_146124 RefSeq | MGI Sequence Detail 3113 C57BL/6  
    polypeptide Q5FWK3 UniProt | EBI | MGI Sequence Detail 439 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 141
      cDNA 141

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2139453
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 1
      Gene Ontology 9
      Phenotypes 18
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory