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Senp1 Gene Detail
Summary
  • Symbol
    Senp1
  • Name
    SUMO1/sentrin specific peptidase 1
  • Synonyms
    2310046A20Rik, D15Ertd528e, E330036L07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445054
    NCBI Gene: 223870
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:97936625-97991625 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 54.04 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1231 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445054
 protein coding gene Chr15:97936625-97991625 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022284
 protein coding gene Chr15:99728121-99785310 (-)
A/J MGP_AJ_G0022243
 protein coding gene Chr15:95779877-95836574 (-)
AKR/J MGP_AKRJ_G0022218
 protein coding gene Chr15:98676206-98729999 (-)
BALB/cJ MGP_BALBcJ_G0022249
 protein coding gene Chr15:96008040-96061226 (-)
C3H/HeJ MGP_C3HHeJ_G0022019
 protein coding gene Chr15:98745986-98802269 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022694
 protein coding gene Chr15:103412914-103468453 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020220
 protein coding gene Chr15:91727746-91786692 (-)
CAST/EiJ MGP_CASTEiJ_G0021541
 protein coding gene Chr15:99626280-99684496 (-)
CBA/J MGP_CBAJ_G0021986
 protein coding gene Chr15:106873607-106930394 (-)
DBA/2J MGP_DBA2J_G0022113
 protein coding gene Chr15:95234392-95287401 (-)
FVB/NJ MGP_FVBNJ_G0022092
 protein coding gene Chr15:94223213-94276220 (-)
LP/J MGP_LPJ_G0022184
 protein coding gene Chr15:99842610-99898783 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022112
 protein coding gene Chr15:110983455-111042803 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022709
 protein coding gene Chr15:98824128-98880030 (-)
PWK/PhJ MGP_PWKPhJ_G0021282
 protein coding gene Chr15:95339136-95394867 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021116
 protein coding gene Chr15:98609133-98663704 (-)
WSB/EiJ MGP_WSBEiJ_G0021590
 protein coding gene Chr15:99340963-99397596 (-)



Homology
more
  • Human Ortholog
    SENP1, SUMO specific peptidase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SENP1, SUMO specific peptidase 1
  • Synonyms
    SuPr-2
  • Links
    NCBI Gene ID: 29843
    neXtProt AC: NX_Q9P0U3
    UniProt: Q9P0U3

  • Chr Location
    12q13.11; chr12:48039784-48106079 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Senp1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    57 phenotypes from 7 alleles in 11 genetic backgrounds
    1 images
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice die before birth. Depending on the allele mice may exhibit placental labyrinth defects and widespread cell death or severe anemia and a defect in definitive erythropoiesis in the fetal liver.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    719
  • Tissues
    8
  • cDNA Data
    132
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 223870 NCBI Gene Model | MGI Sequence Detail 55001 C57BL/6J ±  kb
    transcript NM_001379573 RefSeq | MGI Sequence Detail 6841 ZRU/MplStud  
    polypeptide P59110 UniProt | EBI | MGI Sequence Detail 640 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 133
      cDNA 132
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1261822, MGI:1919167
    References
    more
    • Summaries
      All 100
      Developmental Gene Expression 7
      Diseases 2
      Gene Ontology 11
      Phenotypes 58
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:346178 Lin H, et al., A role and mechanism for redox sensing by SENP1 in beta-cell responses to high fat feeding. Nat Commun. 2024 Jan 6;15(1):334
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory