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Tut4 Gene Detail
Summary
  • Symbol
    Tut4
  • Name
    terminal uridylyl transferase 4
  • Synonyms
    6030404K05Rik, 9230115F04Rik, Tent3a, Zcchc11
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445126
    NCBI Gene: 230594
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:108316623-108416618 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 50.55 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1568 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445126
 protein coding gene Chr4:108316607-108416618 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028555
 protein coding gene Chr4:109198200-109307750 (+)
A/J MGP_AJ_G0028518
 protein coding gene Chr4:105268672-105368698 (+)
AKR/J MGP_AKRJ_G0028465
 protein coding gene Chr4:107886840-107990568 (+)
BALB/cJ MGP_BALBcJ_G0028537
 protein coding gene Chr4:105475126-105578482 (+)
C3H/HeJ MGP_C3HHeJ_G0028251
 protein coding gene Chr4:108612193-108716681 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028977
 protein coding gene Chr4:113122409-113227630 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026268
 protein coding gene Chr4:100558697-100658008 (+)
CAST/EiJ MGP_CASTEiJ_G0027687
 protein coding gene Chr4:106470081-106574770 (+)
CBA/J MGP_CBAJ_G0028220
 protein coding gene Chr4:116846493-116952155 (+)
DBA/2J MGP_DBA2J_G0028368
 protein coding gene Chr4:104903163-105002452 (+)
FVB/NJ MGP_FVBNJ_G0028336
 protein coding gene Chr4:103766221-103868678 (+)
LP/J MGP_LPJ_G0028469
 protein coding gene Chr4:109433936-109551327 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028362
 protein coding gene Chr4:122031979-122147727 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029013
 protein coding gene Chr4:108132502-108237893 (+)
PWK/PhJ MGP_PWKPhJ_G0027413
 protein coding gene Chr4:103166435-103271260 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027237
 protein coding gene Chr4:105465661-105567029 (+)
WSB/EiJ MGP_WSBEiJ_G0027768
 protein coding gene Chr4:108304838-108411921 (+)



Homology
more
  • Human Ortholog
    TUT4, terminal uridylyl transferase 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TUT4, terminal uridylyl transferase 4
  • Synonyms
    PAPD3, TENT3A, ZCCHC11
  • Links
    NCBI Gene ID: 23318
    neXtProt AC: NX_Q5TAX3
    UniProt: Q5TAX3

  • Chr Location
    1p32.3; chr1:52408282-52553487 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TUT4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit partial postnatal lethality associated with postnatal growth retardation and reduced circulating insulin-like growth factor I levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    734
  • Tissues
    19
  • cDNA Data
    10
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034610 Ensembl Gene Model | MGI Sequence Detail 99996 C57BL/6J ±  kb
    transcript ENSMUST00000097925 Ensembl | MGI Sequence Detail 5865 Not Applicable  
    polypeptide ENSMUSP00000095538 Ensembl | MGI Sequence Detail 1648 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2444849, MGI:6155762
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 22
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:357928 Piasecka A, et al., MBNL splicing factors regulate the microtranscriptome of skeletal muscles. Nucleic Acids Res. 2024 Oct 28;52(19):12055-12073
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory